利用血浆微生物游离DNA的下一代测序技术对人工肺瓣膜置换患者的心内膜炎进行诊断和基因分型
Diagnosis and Genotyping of Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA.
作者信息
Kondo Maiko, Dalai Sudeb C, Venkatasubrahmanyam Shivkumar, Eisenberg Nell, Robinson Brian D, Westblade Lars F, Marks Kristen M
机构信息
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York.
Karius, Inc., Redwood City, California.
出版信息
Open Forum Infect Dis. 2019 Jun 1;6(6):ofz242. doi: 10.1093/ofid/ofz242. eCollection 2019 Jun.
Determining the causative etiology of culture-negative endocarditis can be challenging. We performed next-generation sequencing of plasma microbial cell-free DNA to facilitate rapid diagnosis and genotyping of in a patient with culture-negative endocarditis of a prosthetic pulmonary valve, enabling early targeted treatment prior to valve replacement surgery.
确定血培养阴性的心内膜炎的病因具有挑战性。我们对血浆微生物游离DNA进行了二代测序，以促进对一名人工肺动脉瓣血培养阴性的心内膜炎患者进行快速诊断和基因分型，从而在瓣膜置换手术前实现早期靶向治疗。
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