Department of Clinical Laboratory, Wenzhou Medical University Affiliated Dongyang Hospital, Dongyang, Zhejiang, China.
Department of Biomedical Sciences Laboratory, Wenzhou Medical University Affiliated Dongyang Hospital, Dongyang, Zhejiang, China
BMJ Open. 2023 Apr 12;13(4):e067490. doi: 10.1136/bmjopen-2022-067490.
() is the most common opportunistic clinical micro-organism with high drug resistance. This study aimed to analyse the resistance pattern of according to patient age and clinical sample type.
This retrospective observational study was conducted in a tertiary hospital in southeastern China.
strains were isolated from blood, urine and sputum of infected inpatients. The patients were divided into four age groups: children (0-14 years old, including neonatal and non-neonatal groups), youths (15-40 years old), middle-aged (41-60 years old) and old (>60 years old).
A total of 7165 strains were collected from all samples. Compared with urine and blood isolates, more sputum isolates were resistant against 12 tested antibiotics. Furthermore, urine isolates were more resistant to levofloxacin than sputum and blood isolates. Although the patients' age was not associated with resistance rates of strains isolated from blood, a larger proportion of urine-derived strains from youths were resistant to sulfamethoxazole-trimethoprim and piperacillin-tazobactam than those from old people. The sputum strains from the elderly were more resistant to most of the tested antibiotics compared with sputum strains isolated from children.
The resistance profile of is different among age groups and specimen sources and should be considered during infection treatment.
（）是最常见的机会性临床微生物，具有很高的耐药性。本研究旨在根据患者年龄和临床样本类型分析（）的耐药模式。
这是一项在中国东南部一家三级医院进行的回顾性观察研究。
从感染住院患者的血液、尿液和痰液中分离出菌株。将患者分为四个年龄组：儿童（0-14 岁，包括新生儿和非新生儿组）、青年（15-40 岁）、中年（41-60 岁）和老年（>60 岁）。
从所有样本中收集了共 7165 株（）。与尿液和血液分离株相比，更多的痰液分离株对 12 种测试抗生素具有耐药性。此外，尿液分离株对左氧氟沙星的耐药性高于痰液和血液分离株。虽然患者年龄与血液中分离出的（）株的耐药率无关，但青年组尿液分离株对磺胺甲恶唑-甲氧苄啶和哌拉西林-他唑巴坦的耐药率高于老年组。与儿童痰液分离株相比，老年患者的痰液分离株对大多数测试抗生素的耐药性更高。
（）的耐药谱在不同年龄组和标本来源之间存在差异，在治疗（）感染时应予以考虑。
