Hougaard K, Oikawa T, Sveinsdottir E, Skinoj E, Ingvar D H, Lassen N A
Arch Neurol. 1976 Aug;33(8):527-35. doi: 10.1001/archneur.1976.00500080005002.
Regional cerebral blood flow (rCBF) was studied in ten patients with focal cortical epilepsy. The blood flow was measured by the intra-arterial injection of xenon 133 (133Xe), and the isotope clearance was recorded by a multidetector scintillation camera with 254 detectors. Three patients were studied both during a seizure and (in the same setting) in the interictal period; six patients were studied only in the interictal period, and one patient was studied only during a seizure. Studies during seizures all showed marked flow increases in areas presumed to participate in the seizure activity. This finding accords with earlier studies. All nine patients studied in the interictal phase showed, either spontaneously or during activation by intermittent light, focal flow increases in areas presumed to comprise the epileptic focus. These interictal hyperemic foci probably reflect subictal neuronal hyperactivity in epileptogenic nervous tissue. Only two of the patients had distinct epileptic electroencephalographic foci. It appears that rCBF studies can be a valuable diagnostic tool in the investigation of cortical epileptogenic lesions.
对10例局灶性皮质癫痫患者的局部脑血流量（rCBF）进行了研究。通过动脉内注射氙133（133Xe）来测量血流量，并用一台带有254个探测器的多探测器闪烁相机记录同位素清除情况。3例患者在癫痫发作期间以及（在相同条件下）发作间期均接受了研究；6例患者仅在发作间期接受了研究，1例患者仅在癫痫发作期间接受了研究。癫痫发作期间的研究均显示，推测参与癫痫发作活动的区域血流量显著增加。这一发现与早期研究结果一致。在发作间期接受研究的所有9例患者，无论是自发情况下还是在间歇性光照激活期间，推测包含癫痫病灶的区域均出现了局部血流量增加。这些发作间期充血灶可能反映了致痫神经组织的发作期下神经元活动增强。只有2例患者有明确的癫痫脑电图病灶。看来，rCBF研究在皮质致痫性病变的调查中可能是一种有价值的诊断工具。
