Migliari R, Balzano S, Scarpa R M, Campus G, Pintus C, Usai E
Department of Urology, University of Cagliari, Italy.
J Urol. 1988 Mar;139(3):637-9. doi: 10.1016/s0022-5347(17)42549-3.
The effect of short term administration of flutamide on the hypothalamic-pituitary-gonadal axis was studied in six patients with advanced prostate cancer (C2 stage). Flutamide significantly increased LH pulse frequency in all patients (p less than 0.05 by Wilcoxon's test). The FSH pulse analysis disclosed a similar pattern of LH. Plasma IC-T clearly increased following flutamide therapy; mean IC-T values were 2.67 +/- 0.47 ng./ml. and 4.67 +/- 0.62 ng./ml. before and after flutamide administration, respectively (p less than 0.05 by paired Student's t test). Our study demonstrates that flutamide acts in humans as a selective and specific antiandrogen compound.
对6例晚期前列腺癌（C2期）患者研究了短期服用氟他胺对下丘脑-垂体-性腺轴的影响。氟他胺使所有患者的促黄体生成素（LH）脉冲频率显著增加（Wilcoxon检验，p<0.05）。促卵泡生成素（FSH）脉冲分析显示出与LH相似的模式。氟他胺治疗后血浆睾酮（IC-T）明显升高；氟他胺给药前和给药后平均IC-T值分别为2.67±0.47 ng/ml和4.67±0.62 ng/ml（配对t检验，p<0.05）。我们的研究表明，氟他胺在人体内作为一种选择性和特异性抗雄激素化合物发挥作用。
