Benikova E A, Reznikov A G, Varga S V, Boiarskaia O Ia, Demchenko V N
Probl Endokrinol (Mosk). 1985 May-Jun;31(3):26-9.
A study was made of a possibility to use a test with the administration of the nonsteroid antiandrogen flutamide to male patients with testicular hypogonadism to evaluate the gonadotropic reserves in this pathology and differential diagnosis of the pathogenetically different forms of this diseases in male patients aged 12 to 33. Flutamide was prescribed for internal use, 10 mg/kg a day for 5 days. Functional reserves of the hypothalamo-hypophyseal-gonadal system were estimated by the change of LH secretion with morning and daily urine after 3 and 5 days as well as by the LH, FSH and T content in the blood plasma. A significant rise of LH excretion with morning and daily urine was noted in patients with primary hypogonadism receiving flutamide. On the contrary, no significant changes in LH secretion under the influence of flutamide were detected in secondary hypogonadism. It is suggestive of the preservation of the gonadotropic reserves in primary hypogonadism and their absence in secondary hypogonadism. The test is proposed for differential diagnosis in diagnostic difficulties. The most accurate results are obtained by using LH in the urine collected for 3 days of flutamide intake.
对12至33岁男性睾丸功能减退患者使用非甾体类抗雄激素氟他胺进行检测，以评估该病理状态下的促性腺激素储备，并对该疾病不同发病机制形式进行鉴别诊断的可能性进行了研究。氟他胺口服给药，每日10mg/kg，共5天。通过服药3天和5天后晨尿及全日尿中LH分泌的变化以及血浆中LH、FSH和T的含量来评估下丘脑 - 垂体 - 性腺系统的功能储备。接受氟他胺治疗的原发性性腺功能减退患者晨尿及全日尿中LH排泄量显著增加。相反，继发性性腺功能减退患者在氟他胺影响下LH分泌无显著变化。这表明原发性性腺功能减退中促性腺激素储备得以保留，而继发性性腺功能减退中则不存在。该检测方法可用于诊断困难时的鉴别诊断。服用氟他胺3天收集的尿液中LH检测结果最为准确。
