Reznikov A G, Varga S V, Benikova E A, Boiarskaia O Ia, Volkova N N
Probl Endokrinol (Mosk). 1985 Mar-Apr;31(2):15-8.
A study was made of a possibility to use a nonsteroidal antiandrogen flutamide to investigate the gonadotropic reserves of the hypothalamo-hypophysial system. In healthy males aged 12 to 36, the intake of flutamide tablets at a dose of 10 mg/kg bw for 3 or 5 days was accompanied by an increase in the LH excretion and general gonadotropic activity in the daily urine by 1.5-2 times and more. An elevation of the gonadotrophin level in morning urine portions was less noticeable. The LH level in the blood plasma did not change, that of FSH and testosterone increased but in certain age groups. For purposes of functional diagnosis it was suggested that the gonadotrophin level in the daily urine should be studied prior to and after 3- or 5-day of flutamide intake.
开展了一项关于使用非甾体类抗雄激素氟他胺来研究下丘脑 - 垂体系统促性腺激素储备可能性的研究。在12至36岁的健康男性中，以10mg/kg体重的剂量服用氟他胺片3天或5天，每日尿液中促黄体生成素（LH）排泄量和总体促性腺激素活性增加了1.5至2倍甚至更多。晨尿部分中促性腺激素水平的升高不太明显。血浆中的LH水平没有变化，促卵泡生成素（FSH）和睾酮水平在特定年龄组中有所升高。为进行功能诊断，建议在服用氟他胺3天或5天之前和之后研究每日尿液中的促性腺激素水平。
