Ball M J, White K
Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK.
Intensive Care Med. 1989;15(4):250-4. doi: 10.1007/BF00271061.
The metabolic effects of an intravenous lipid emulsion containing medium chain triglycerides (MCTs) were studied in eleven critically ill, ventilated patients receiving parenteral nutrition. The effects were compared in a cross-over study with those of a conventional emulsion containing only long chain triglycerides (LCTs). The lipid was well tolerated, but there were differences in the metabolic effects with a significantly greater increase in the plasma concentrations of glycerol and ketones during MCT/LCT infusion compared to LCT. The plasma concentration of non esterified fatty acids was also higher. This fell rapidly post infusion. Since non esterified fatty acids and ketones are readily available energy sources for tissues lipid emulsions containing MCT may prove valuable for catabolic, critically ill patients.
在11名接受肠外营养的危重症机械通气患者中，研究了一种含中链甘油三酯（MCT）的静脉脂质乳剂的代谢效应。在一项交叉研究中，将其效应与仅含长链甘油三酯（LCT）的传统乳剂的效应进行了比较。该脂质耐受性良好，但代谢效应存在差异，与LCT相比，MCT/LCT输注期间甘油和酮的血浆浓度显著升高。非酯化脂肪酸的血浆浓度也较高。输注后迅速下降。由于非酯化脂肪酸和酮是组织容易利用的能量来源，含MCT的脂质乳剂可能对分解代谢的危重症患者有价值。
