一种基于 BODIPY 的比率型探针，用于检测和成像活细胞中的多硫化氢。
A BODIPY-based ratiometric probe for sensing and imaging hydrogen polysulfides in living cells.
机构信息
Key Laboratory of Advanced Functional Materials of Nanjing, School of Environmental Science, Nanjing Xiaozhuang University, Nanjing 211171, China.
Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Dec 5;223:117295. doi: 10.1016/j.saa.2019.117295. Epub 2019 Jun 19.
Hydrogen polysulfides (HS, n > 1) have attracted increasing attention in biological systems due to its redox signaling effect. To illustrate the process of the physiological and pathological roles played by HS, accurate detection is highly desired. In this work, we report a BODIPY-based fluorescent probe (BDP-PHS) for ratiometric HS sensing. BDP-PHS shows higher sensitivity and selectivity ratiometric response toward HS than various biological related species. Moreover, BDP-PHS has been successfully applied in imaging of HS in living cells.
氢多硫化物（HS，n > 1）由于其氧化还原信号作用，在生物系统中受到越来越多的关注。为了说明 HS 发挥生理和病理作用的过程，人们非常希望能够对其进行准确检测。在这项工作中，我们报告了一种基于 BODIPY 的荧光探针（BDP-PHS），用于 HS 的比率型传感。BDP-PHS 对 HS 的比率型响应比各种生物相关物种具有更高的灵敏度和选择性。此外，BDP-PHS 已成功应用于活细胞中 HS 的成像。
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