急性脑血管病患者大剂量皮质类固醇治疗的胃肠道并发症

Gastrointestinal complication of high-dose corticosteroid therapy in acute cerebrovascular patients.

作者信息

Ottonello G A, Primavera A

出版信息

Stroke. 1979 Mar-Apr;10(2):208-10. doi: 10.1161/01.str.10.2.208.

DOI:10.1161/01.str.10.2.208

Abstract

Corticosteroids are commonly used in the treatment of stroke, although their clinical effectiveness has not been established. Side effects, especially gastrointestinal complications, occur in patients with cerebral disease. A necroscopy study of 124 patients investigated the occurrence of gastrointestinal lesions in patients with acute stroke treated with high-dose of corticosteroids compared to untreated patients with stroke and to patients dying from non-vascular neurological diseases. A significant relationship between the use of steroids and gastrointestinal lesion in strokes is demonstrated.

摘要

皮质类固醇常用于中风治疗，但其临床疗效尚未得到证实。患有脑部疾病的患者会出现副作用，尤其是胃肠道并发症。一项对124名患者的尸检研究调查了与未接受治疗的中风患者以及死于非血管性神经疾病的患者相比，接受高剂量皮质类固醇治疗的急性中风患者胃肠道病变的发生情况。研究表明，中风患者使用类固醇与胃肠道病变之间存在显著关联。