Pezner R D, Lipsett J A
West J Med. 1982 Nov;137(5):375-8.
A retrospective analysis was done of 106 patients who received radiation therapy for brain metastasis. Dexamethasone therapy was instituted in 97 patients. Peptic ulcer disease developed in 5 of 89 patients (5.6 percent) who received a dosage of at least 12 mg a day, but did not occur in patients who received a lower dose or in those who did not receive steroids. The interval between institution of dexamethasone therapy and the development of peptic ulcer disease ranged from three to nine weeks. Two patients had perforated ulcers, one of whom required surgical resection. Peptic ulcer disease contributed to the general deterioration and death of three of the five patients. Overall, in 14 of the 89 patients (15.7 percent) a complication of steroid therapy developed in the form of peptic ulcer disease, steroid myopathy or diabetes mellitus (or a combination of these).
对106例接受脑转移瘤放射治疗的患者进行了回顾性分析。97例患者采用了地塞米松治疗。在89例每天接受至少12毫克剂量治疗的患者中，有5例（5.6%）发生了消化性溃疡疾病，而接受较低剂量治疗的患者或未接受类固醇治疗的患者未出现这种情况。地塞米松治疗开始至消化性溃疡疾病发生的间隔时间为3至9周。2例患者出现溃疡穿孔，其中1例需要手术切除。消化性溃疡疾病导致了5例患者中3例的全身状况恶化和死亡。总体而言，89例患者中有14例（15.7%）出现了类固醇治疗的并发症，表现为消化性溃疡疾病、类固醇肌病或糖尿病（或这些情况的组合）。
