Department of Endocrinology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou 225300, Jiangsu, China.
Department of Cardiology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou 225300, Jiangsu, China.
Med Clin (Barc). 2020 Mar 13;154(5):151-156. doi: 10.1016/j.medcli.2019.04.019. Epub 2019 Jun 26.
Previous observational studies have suggested that low vitamin D status is associated with high circulating C-reactive protein levels, as well as other plasma inflammatory cytokines. However, there is no study to explore the relationship between vitamin D status and Lp-PLA2, a new biomarker of vascular-specific inflammation. The aim of this study was to examine the association between vitamin D status and circulating Lp-PLA2 levels in subjects with type 2 diabetes mellitus.
This descriptive cross-sectional study enrolled diabetic subjects who underwent physical examination at Taizhou People's Hospital between August 2016 and January 2017. Blood pressure, anthropometry, metabolic profiles, serum 25(OH)D levels and Lp-PLA2 mass levels were measured in all participants.
A total of 196 participants were recruited into this study. The vitamin D insufficiency group had higher serum LP-PLA2 levels than the vitamin D sufficiency group (t=-2.765, p=.005). A significant negative correlation was noted between Lp-PLA2 and 25(OH)D in the vitamin D insufficiency group (r=-0.364, p=0.009). However, no significant relationship between serum Lp-PLA2 concentration and 25(OH)D levels was observed in subjects with vitamin D sufficiency.
From this cohort of patients with type 2 diabetes, regardless of traditional cardiovascular risk factors, we observed a statistically significant inverse relation between Lp-PLA2 and 25(OH)D at levels <30ng/mL.
先前的观察性研究表明，维生素 D 状态较低与循环 C 反应蛋白水平升高以及其他血浆炎性细胞因子有关。然而，目前尚无研究探讨维生素 D 状态与脂蛋白相关磷脂酶 A2（一种新的血管特异性炎症生物标志物）之间的关系。本研究旨在探讨 2 型糖尿病患者的维生素 D 状态与循环 Lp-PLA2 水平之间的关系。
本研究为描述性横断面研究，纳入了 2016 年 8 月至 2017 年 1 月期间在台州人民医院进行体检的糖尿病患者。所有参与者均测量了血压、人体测量学、代谢特征、血清 25（OH）D 水平和 Lp-PLA2 质量水平。
共纳入 196 名参与者。与维生素 D 充足组相比，维生素 D 不足组的血清 LP-PLA2 水平更高（t=-2.765，p=.005）。在维生素 D 不足组中，Lp-PLA2 与 25（OH）D 之间存在显著负相关（r=-0.364，p=0.009）。然而，在维生素 D 充足的受试者中，血清 Lp-PLA2 浓度与 25（OH）D 水平之间没有显著的关系。
在本队列的 2 型糖尿病患者中，无论是否存在传统的心血管危险因素，我们观察到在 25（OH）D<30ng/mL 水平时，Lp-PLA2 与 25（OH）D 之间存在统计学显著的负相关关系。
