Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Exp Gerontol. 2019 Sep;124:110643. doi: 10.1016/j.exger.2019.110643. Epub 2019 Jun 28.
Prolonged bed rest and lifelong physical inactivity cause deleterious effects to multiple physiological systems that appear to hasten aging processes. Many such changes are similar to those seen with microgravity in space, but at a much faster rate. Head down tilt bed rest models are used to study whole-body changes that occur with spaceflight. We propose that bed rest can be used to quantify accelerated human aging in relation to frailty. In particular, frailty as a measure of the accumulation of deficits estimates the variability in aging across systems, and moves away from the traditional single-system approach. Here, we provide an overview of the impact of bed rest on the musculoskeletal and cardiovascular systems as well as frailty-related biological markers and inflammatory cytokines. We also propose future inquiries to study the accumulation of deficits with head down bed rest and bed rest in the clinical setting, specifically to understand how unrepaired and unremoved subclinical and subcellular damage give rise to clinically observable health problems.
长时间卧床休息和终身缺乏身体活动会对多个生理系统造成有害影响，这些影响似乎加速了衰老过程。许多这样的变化与太空中的微重力相似，但速度要快得多。头低位卧床休息模型被用于研究与太空飞行相关的全身变化。我们提出，卧床休息可用于量化与虚弱相关的加速人类衰老。具体来说，作为缺陷累积的衡量标准，虚弱可以估计不同系统之间的衰老变异性，并摆脱传统的单一系统方法。在这里，我们概述了卧床休息对肌肉骨骼和心血管系统以及与虚弱相关的生物标志物和炎症细胞因子的影响。我们还提出了未来的研究建议，以研究头低位卧床休息和临床环境中的卧床休息中缺陷的积累，特别是为了了解未修复和未去除的亚临床和亚细胞损伤如何导致临床上可观察到的健康问题。
