睡眠与昼夜节律医学：神经科诊室的时间。
Sleep and Circadian Medicine: Time of Day in the Neurologic Clinic.
机构信息
Division of Human Genetics, Department of Pediatrics, Center for Chronobiology, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA; Division of Immunobiology, Department of Pediatrics, Center for Chronobiology, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.
Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
出版信息
Neurol Clin. 2019 Aug;37(3):615-629. doi: 10.1016/j.ncl.2019.03.004. Epub 2019 May 11.
Fundamental aspects of neurobiology are time-of-day regulated. Therefore, it is not surprising that neurodegenerative and psychiatric diseases are accompanied by sleep and circadian rhythm disruption. Although the direction of causation remains unclear, abnormal sleep-wake patterns often occur early in disease, exacerbate progression, and are a common primary complaint from patients. Circadian medicine incorporates knowledge of 24-hour biological rhythms to improve treatment. This article highlights how research and technologic advances in circadian biology might translate to improved patient care.
神经生物学的基本方面受时间调控。因此，神经退行性和精神疾病伴随着睡眠和昼夜节律紊乱并不奇怪。尽管因果关系尚不清楚，但异常的睡眠-觉醒模式通常在疾病早期出现，会加重病情进展，也是患者常见的主要抱怨。昼夜节律医学整合了对 24 小时生物节律的认识，以改善治疗效果。本文重点介绍了昼夜节律生物学研究和技术进步如何转化为改善患者护理。
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