Hyndiuk R A, Skorich D N, Davis S D, Sarff L D, Divine K, Burd E
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee.
Am J Ophthalmol. 1988 Mar 15;105(3):239-43. doi: 10.1016/0002-9394(88)90002-5.
We conducted experiments to determine the effectiveness of fortified antibiotic ointment in the treatment of Pseudomonas keratitis in rabbits. We evaluated gentamicin ointment (3, 10, 20, and 40 mg/g), gentamicin solution (3 and 10 mg/ml), and placebo, each given every 30 minutes. We also examined the effectiveness of fortified ointment given in extended treatment intervals. In short-term trials, commercial-strength gentamicin solution (3 mg/ml) was therapeutically superior (P less than .001) to commercial-strength gentamicin ointment (3 mg/g) in reducing corneal bacterial colony counts. No significant difference in antimicrobial effect was noted between fortified gentamicin ointment and fortified gentamicin solution at 30-minute treatment intervals. Fortified gentamicin ointment reduced colony counts even at extended treatment intervals of up to four hours in a severe keratitis model.
我们进行了实验，以确定强化抗生素眼膏治疗兔铜绿假单胞菌性角膜炎的有效性。我们评估了庆大霉素眼膏（3、10、20和40mg/g）、庆大霉素溶液（3和10mg/ml）以及安慰剂，每种药物每30分钟给药一次。我们还研究了延长给药间隔时强化眼膏的有效性。在短期试验中，市售浓度的庆大霉素溶液（3mg/ml）在减少角膜细菌菌落计数方面在治疗上优于市售浓度的庆大霉素眼膏（3mg/g）（P小于0.001）。在30分钟的给药间隔下，强化庆大霉素眼膏和强化庆大霉素溶液在抗菌效果上没有显著差异。在严重角膜炎模型中，即使在长达4小时的延长给药间隔下，强化庆大霉素眼膏也能减少菌落计数。
