Insler M S, Robbins R G, Martinez M T, Johnson M K
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112.
CLAO J. 1988 Jul-Sep;14(3):148-50.
In an experimental model of Pseudomonas keratitis, 50 rabbit eyes were treated with gentamicin sulfate (3 mg/mL) prophylactically on four different treatment regimens. One group (13 eyes) received one drop of gentamicin sulfate every hour to a total of four drops, the last drop 25 minutes before inoculation. A second group (13 eyes) was given one drop of gentamicin sulfate one hour before inoculation. A third group (12 eyes) received one drop of gentamicin sulfate per minute to a total of 4 drops, the last drop 25 minutes prior to inoculation. A fourth group (12 eyes) received one drop of antibiotic 25 minutes before inoculation. Twelve control eyes received saline solution. Subsequently, a superficial corneal scratch was inflicted and each eye received one drop (0.05 mL) of a solution containing Pseudomonas aeruginosa. The infection rate in all four experimental groups was low, whereas all control eyes became infected. These results demonstrate the effectiveness of prophylactic antibiotic application in the prevention of Pseudomonas keratitis prior to superficial ocular trauma.
在铜绿假单胞菌角膜炎的实验模型中，50只兔眼采用四种不同治疗方案预防性使用硫酸庆大霉素（3mg/mL）。一组（13只眼）每小时滴注一滴硫酸庆大霉素，共滴注四滴，最后一滴在接种前25分钟滴入。第二组（13只眼）在接种前一小时滴注一滴硫酸庆大霉素。第三组（12只眼）每分钟滴注一滴硫酸庆大霉素，共滴注4滴，最后一滴在接种前25分钟滴入。第四组（12只眼）在接种前25分钟滴注一滴抗生素。12只对照眼滴注生理盐水。随后，对角膜进行浅表划痕，每只眼滴入一滴（0.05mL）含铜绿假单胞菌的溶液。所有四个实验组的感染率都很低，而所有对照眼均被感染。这些结果证明了预防性应用抗生素在预防眼表创伤前铜绿假单胞菌角膜炎方面的有效性。
