一种合成-氧代-2,5-二酮哌嗪的扩环方法。
A Ring Expansion Approach To -oxy-2,5-diketopiperazines.
作者信息
Jackson Amy C, Olsen James T, Sundstrom Sasha, Lambert Kyle M, Wood John L
机构信息
Department of Chemistry and Biochemistry, Baylor University, Waco, TX, 76706.
出版信息
Tetrahedron Lett. 2022 Jun 8;99. doi: 10.1016/j.tetlet.2022.153851. Epub 2022 May 18.
Abstract
A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to -oxy-2,5-diketopiperazines (DKPs) is described. This method allows for the facile and late-stage construction of the hydroxamic acid moiety and can thereby serve as a general method for accessing -oxy-2,5-DKP natural products.
摘要
本文描述了一种将四胺酸（吡咯烷-2,4-二酮）环化扩展为2,5-二酮哌嗪（DKP）的方法。该方法能够简便地在后期构建异羟肟酸部分，从而可作为一种通用方法用于获取2,5-二酮哌嗪类天然产物。
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