氟卡尼在人体组织中的分布。
Flecainide distribution in human tissues.
作者信息
Latini R, Cavalli A, Maggioni A P, Volpi A
机构信息
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
出版信息
Br J Clin Pharmacol. 1987 Dec;24(6):820-2. doi: 10.1111/j.1365-2125.1987.tb03252.x.
Abstract
The distribution of antiarrhythmic drugs in human tissues may yield a better understanding of their therapeutic action and side effects. We report tissue distribution of flecainide in a patient who died suddenly while being treated chronically with the drug. Lungs showed the highest concentration of flecainide (143 micrograms g-1 wet tissue); liver, kidney and heart, in decreasing order, have good affinity for the drug. Flecainide was present also in the central nervous system in lower concentrations. The lowest concentration was found in the adipose tissue.
摘要
抗心律失常药物在人体组织中的分布情况有助于更好地理解其治疗作用和副作用。我们报告了一名长期服用氟卡尼治疗期间突然死亡患者的氟卡尼组织分布情况。肺组织中氟卡尼浓度最高（143微克/克湿组织）；肝脏、肾脏和心脏对该药物的亲和力依次降低。氟卡尼在中枢神经系统中的浓度也较低。脂肪组织中的浓度最低。
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本文引用的文献
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Clinical pharmacokinetics of amiodarone.胺碘酮的临床药代动力学。
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