• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Flecainide distribution in human tissues.氟卡尼在人体组织中的分布。
Br J Clin Pharmacol. 1987 Dec;24(6):820-2. doi: 10.1111/j.1365-2125.1987.tb03252.x.
2
Dose-dependent tissue uptake of flecainide during chronic administration in rabbits.在兔慢性给药期间，氟卡尼的组织摄取呈剂量依赖性。
Drug Metab Dispos. 1988 Mar-Apr;16(2):228-31.
3
[Concentrations of amiodarone and flecainide in plasma and saliva--indications for the active transport of flecainide].[血浆和唾液中胺碘酮与氟卡尼的浓度——氟卡尼主动转运的指征]
Z Kardiol. 1988 Feb;77(2):99-102.
4
Flecainide intoxication.氟卡尼中毒
J Anal Toxicol. 1990 Sep-Oct;14(5):335-6. doi: 10.1093/jat/14.5.335.
5
Flecainide distribution, transplacental passage, and accumulation in the amniotic fluid during the third trimester of pregnancy.孕期第三个月期间氟卡尼的分布、经胎盘转运及在羊水中的蓄积情况。
Ann Pharmacother. 1994 Sep;28(9):1031-4. doi: 10.1177/106002809402800907.
6
Mechanism of flecainide's rate-dependent actions on action potential duration in canine atrial tissue.氟卡尼对犬心房组织动作电位时程的频率依赖性作用机制。
J Pharmacol Exp Ther. 1993 Nov;267(2):575-81.
7
Flecainide enantiomers: disposition in human subjects and electrophysiologic actions in vitro.氟卡尼对映体：在人体中的处置及体外电生理作用
Clin Pharmacol Ther. 1989 Nov;46(5):584-90. doi: 10.1038/clpt.1989.189.
8
[Pharmacodynamics and pharmacokinetics of flecainide in cardiac pre-excitation of the bundle of Kent].[氟卡尼在肯特束心脏预激中的药效学与药代动力学]
Cardiologia. 1989 May;34(5):425-9.
9
Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.氟卡尼致QRS波增宽的药代动力学-药效学模型：清醒遥测犬窦性心律时心率依赖性效应
J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):24-9. doi: 10.1016/j.vascn.2013.10.001. Epub 2013 Oct 16.
10
Encainide hydrochloride and flecainide acetate: two class 1c antiarrhythmic agents.盐酸恩卡尼和醋酸氟卡尼：两种1C类抗心律失常药。
Clin Pharm. 1987 Nov;6(11):839-50.

引用本文的文献

1
Flecainide-Induced Acute Respiratory Distress Syndrome: A Case Report.氟卡尼诱发的急性呼吸窘迫综合征：一例报告
Cureus. 2024 Jun 4;16(6):e61637. doi: 10.7759/cureus.61637. eCollection 2024 Jun.
2
Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells.氟卡尼对透化的野生型心室肌细胞中的兰尼碱受体2（RyR2）产生持续的依赖于逆流的效应，但对完整细胞则无此效应。
Front Pharmacol. 2023 Apr 12;14:1155601. doi: 10.3389/fphar.2023.1155601. eCollection 2023.
3
Flecainide-induced pneumonitis: a case report.氟卡尼导致的肺炎：一例报告。
J Med Case Rep. 2022 Nov 2;16(1):404. doi: 10.1186/s13256-022-03619-w.
4
Drug-induced acute pneumonitis following initiation of flecainide therapy after pulmonary vein isolation ablation in a patient with mitral stenosis and previous chronic amiodarone use.一名二尖瓣狭窄且既往使用过慢性胺碘酮的患者，在肺静脉隔离消融术后开始使用氟卡尼治疗后发生药物性急性肺炎。
HeartRhythm Case Rep. 2018 Nov 4;5(1):53-55. doi: 10.1016/j.hrcr.2018.10.013. eCollection 2019 Jan.
5
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia.氟卡尼在儿茶酚胺能多形性室性心动过速中的三重作用模式。
Cardiovasc Res. 2013 May 1;98(2):326-7. doi: 10.1093/cvr/cvt059. Epub 2013 Mar 19.
6
Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism.CYP2D6 基因型对氟卡尼代谢随年龄变化的影响：CYP1A2 介导代谢的参与。
Br J Clin Pharmacol. 2009 Jul;68(1):89-96. doi: 10.1111/j.1365-2125.2009.03435.x.

本文引用的文献

1
Application of a bonded-phase extraction column for rapid sample preparation of flecainide from human plasma for high-performance liquid chromatographic analysis--fluorescence or ultraviolet detection.
Ther Drug Monit. 1984;6(1):105-11. doi: 10.1097/00007691-198403000-00017.
2
Clinical pharmacokinetics of amiodarone.胺碘酮的临床药代动力学。
Clin Pharmacokinet. 1984 Mar-Apr;9(2):136-56. doi: 10.2165/00003088-198409020-00002.
3
Flecainide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy.氟卡尼。对其药效学特性和治疗效果的初步综述。
Drugs. 1985 Jan;29(1):1-33. doi: 10.2165/00003495-198529010-00001.
4
Distribution of propafenone and its active metabolite, 5-hydroxypropafenone, in human tissues.普罗帕酮及其活性代谢产物5-羟基普罗帕酮在人体组织中的分布。
Am Heart J. 1987 Mar;113(3):843-4. doi: 10.1016/0002-8703(87)90735-6.
5
Plasma and tissue levels of flecainide in rats.大鼠体内氟卡尼的血浆和组织水平。
Pharmacol Res Commun. 1986 Aug;18(8):739-45. doi: 10.1016/0031-6989(86)90115-3.

氟卡尼在人体组织中的分布。

Flecainide distribution in human tissues.

作者信息

Latini R, Cavalli A, Maggioni A P, Volpi A

机构信息

Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

出版信息

Br J Clin Pharmacol. 1987 Dec;24(6):820-2. doi: 10.1111/j.1365-2125.1987.tb03252.x.

DOI:10.1111/j.1365-2125.1987.tb03252.x
PMID:3125854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1386410/
Abstract

The distribution of antiarrhythmic drugs in human tissues may yield a better understanding of their therapeutic action and side effects. We report tissue distribution of flecainide in a patient who died suddenly while being treated chronically with the drug. Lungs showed the highest concentration of flecainide (143 micrograms g-1 wet tissue); liver, kidney and heart, in decreasing order, have good affinity for the drug. Flecainide was present also in the central nervous system in lower concentrations. The lowest concentration was found in the adipose tissue.

摘要

抗心律失常药物在人体组织中的分布情况有助于更好地理解其治疗作用和副作用。我们报告了一名长期服用氟卡尼治疗期间突然死亡患者的氟卡尼组织分布情况。肺组织中氟卡尼浓度最高（143微克/克湿组织）；肝脏、肾脏和心脏对该药物的亲和力依次降低。氟卡尼在中枢神经系统中的浓度也较低。脂肪组织中的浓度最低。