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氟卡尼诱发的急性呼吸窘迫综合征：一例报告

Flecainide-Induced Acute Respiratory Distress Syndrome: A Case Report.

作者信息

Schneegurt Noah R, Wright Christian, Glenn Neil, Thethi Inderpal

机构信息

Internal Medicine, Mount Carmel Health System, Grove City, USA.

Pulmonary and Critical Care Medicine, Mount Carmel Health System, Columbus, USA.

出版信息

Cureus. 2024 Jun 4;16(6):e61637. doi: 10.7759/cureus.61637. eCollection 2024 Jun.

DOI:10.7759/cureus.61637
PMID:38975498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11227613/
Abstract

Flecainide is an antiarrhythmic drug that rarely causes lung injury. We present a case of flecainide-induced lung injury (FILI) that resulted in acute respiratory distress syndrome (ARDS) and resolved after flecainide discontinuation and corticosteroid treatment. FILI has been shown to occur days to two years after treatment initiation. Our presented case shows that FILI can occur after at least five years of therapy and is the first to show lung injury after a period of flecainide cessation and subsequent re-initiation. Clinical impacts may be large, as flecainide becomes more commonplace in medical pharmacopeia.

摘要

氟卡尼是一种很少引起肺损伤的抗心律失常药物。我们报告一例氟卡尼诱发的肺损伤（FILI），该损伤导致急性呼吸窘迫综合征（ARDS），在停用氟卡尼并进行皮质类固醇治疗后病情得到缓解。已证明FILI在治疗开始后数天至两年内发生。我们报告的病例表明，FILI可在至少五年的治疗后发生，并且是首例在氟卡尼停药一段时间后重新开始使用又出现肺损伤的病例。随着氟卡尼在医学药典中变得越来越常见，其临床影响可能很大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0adb/11227613/95ea69f6d93a/cureus-0016-00000061637-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0adb/11227613/aa9f709e4fff/cureus-0016-00000061637-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0adb/11227613/95ea69f6d93a/cureus-0016-00000061637-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0adb/11227613/aa9f709e4fff/cureus-0016-00000061637-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0adb/11227613/95ea69f6d93a/cureus-0016-00000061637-i02.jpg

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本文引用的文献

1
Flecainide-induced pneumonitis: a case report.氟卡尼导致的肺炎：一例报告。
J Med Case Rep. 2022 Nov 2;16(1):404. doi: 10.1186/s13256-022-03619-w.
2
Drug-induced acute pneumonitis following initiation of flecainide therapy after pulmonary vein isolation ablation in a patient with mitral stenosis and previous chronic amiodarone use.一名二尖瓣狭窄且既往使用过慢性胺碘酮的患者，在肺静脉隔离消融术后开始使用氟卡尼治疗后发生药物性急性肺炎。
HeartRhythm Case Rep. 2018 Nov 4;5(1):53-55. doi: 10.1016/j.hrcr.2018.10.013. eCollection 2019 Jan.
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Drug-Induced Interstitial Lung Disease: A Systematic Review.
药物性间质性肺疾病：一项系统评价
J Clin Med. 2018 Oct 15;7(10):356. doi: 10.3390/jcm7100356.
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Flecainide: Current status and perspectives in arrhythmia management.氟卡尼：心律失常管理的现状与展望
World J Cardiol. 2015 Feb 26;7(2):76-85. doi: 10.4330/wjc.v7.i2.76.
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Diffuse infiltrative lung disease associated with flecainide. Report of two cases.与氟卡尼相关的弥漫性浸润性肺病。两例报告。
Respiration. 2002;69(2):182-5. doi: 10.1159/000056325.
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Flecainide distribution in human tissues.氟卡尼在人体组织中的分布。
Br J Clin Pharmacol. 1987 Dec;24(6):820-2. doi: 10.1111/j.1365-2125.1987.tb03252.x.
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Flecainide-associated interstitial pneumonitis.氟卡尼相关性间质性肺炎。
Lancet. 1991 Feb 9;337(8737):371-2. doi: 10.1016/0140-6736(91)91010-r.
8
Mechanism of flecainide's antiarrhythmic action in experimental atrial fibrillation.氟卡尼在实验性心房颤动中的抗心律失常作用机制
Circ Res. 1992 Aug;71(2):271-87. doi: 10.1161/01.res.71.2.271.