1,25-二羟基维生素D与维生素D结合蛋白在牙周炎中的关系
The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis.
作者信息
Rafique Sara, Hingorjo Mozaffer Rahim, Mumtaz Mahparah, Qureshi Masood Anwar
机构信息
Dr. Sara Rafique, MPhil, Department of Physiology, Jinnah Medical & Dental College, Karachi, Pakistan.
Prof. Mozaffer Rahim Hingorjo, PhD, Department of Physiology, Jinnah Medical & Dental College, Karachi, Pakistan.
出版信息
Pak J Med Sci. 2019;35(3):847-851. doi: 10.12669/pjms.35.3.482.
OBJECTIVE
This study was conducted to explore the relationship between 1,25-dihydroxy vitamin D (1,25(OH)D) and Vitamin-D binding protein (DBP) in patients with periodontitis and healthy controls.
METHODS
Seventy-five periodontitis cases were recruited from the dental OPD of Dow University of Health Sciences, Karachi. Diagnostic criteria of periodontitis were followed according to the probe pocket depth and clinical attachment loss. Seventy-five periodontal healthy controls were selected from the faculty and students of same university. Serum levels of 1,25(OH)D and DBP were determined by ELISA.
RESULTS
Significantly low levels of 1,25(OH)D and high levels of serum DBP were observed in periodontitis patients compared to healthy controls (<0.05), with levels of DBP increasing significantly with the severity of periodontitis (=0.005). Concentrations of DBP correlated positively with 1,25(OH)D, especially in cases with periodontitis (r =0.780; p<0.001).
CONCLUSION
Within the limits of the study, we conclude that low 1,25(OH)D levels and high DBP levels are associated with periodontitis.
目的
本研究旨在探讨牙周炎患者与健康对照者中1,25 - 二羟基维生素D（1,25(OH)D）和维生素D结合蛋白（DBP）之间的关系。
方法
从卡拉奇道健康科学大学牙科门诊招募了75例牙周炎患者。根据探诊袋深度和临床附着丧失情况遵循牙周炎的诊断标准。从同一大学的教职工和学生中选取75名牙周健康对照者。采用酶联免疫吸附测定法（ELISA）测定血清1,25(OH)D和DBP水平。
结果
与健康对照者相比，牙周炎患者的1,25(OH)D水平显著降低，血清DBP水平升高（<0.05），且DBP水平随牙周炎严重程度显著升高（=0.005）。DBP浓度与1,25(OH)D呈正相关，尤其是在牙周炎患者中（r =0.780；p<0.001）。
结论
在本研究范围内，我们得出结论，低水平的1,25(OH)D和高水平的DBP与牙周炎有关。
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