代谢综合征患者中与高甘油三酯血症相关的神经病变
NEUROPATHY ASSOCIATED WITH HYPERTRIGLYCERIDEMIA IN PATIENTS WITH METABOLIC SYNDROME.
作者信息
Beyca H H, Mesci B, Telci Caklili O, Mutlu H H, Oguz A
机构信息
Istanbul, Turkey.
Medeniyet University Goztepe Training and Research Hospital, Dept. of Internal Medicine, Turkey.
出版信息
Acta Endocrinol (Buchar). 2016 Jan-Mar;12(1):26-29. doi: 10.4183/aeb.2016.26.
CONTEXT
With more studies investigating effects of high serum lipid levels, new findings are emerging regarding the damage these biomolecules may cause.
AIM
In this study we aimed to find a relation between neuropathy and hypertriglyceridemia in patients with metabolic syndrome (MS).
MATERIAL AND METHODS
One hundred and twenty subjects (Ninety subjects with metabolic syndrome and 30 healthy controls) were included in the study. Subjects with MS were divided into three groups. HbA1C levels of the subjects were < 5.7% in group A, ≥ 5.7% - < 6.5% in group B, and ≥ 6.5% - < 8.0% in group C. Pin-Prick test and Semmes- Weinstein Monofilament were used for neurological examination. Electromyography was performed to patients with neuropathy to support the diagnosis.
RESULTS
Neuropathy prevalence was found to be higher in the subjects with metabolic syndrome compared to control group. (9.9 %; 16.65 %; 23.31 % . 3.3%; in group A, group B, group C . healthy control group respectively) (p=0.003 for group A, p=0.0002 for group B, p=0.0002 for group C). There was an association between triglyceride levels and neuropathy in group C.
CONCLUSION
Patients with MS may have more neuropathy risk than we estimate.
背景
随着越来越多的研究调查高血清脂质水平的影响，关于这些生物分子可能造成的损害出现了新的发现。
目的
在本研究中，我们旨在寻找代谢综合征（MS）患者神经病变与高甘油三酯血症之间的关系。
材料与方法
本研究纳入了120名受试者（90名代谢综合征患者和30名健康对照者）。患有MS的受试者被分为三组。A组受试者的糖化血红蛋白（HbA1C）水平<5.7%，B组≥5.7% - <6.5%，C组≥6.5% - <8.0%。采用针刺试验和Semmes-Weinstein单丝进行神经学检查。对患有神经病变的患者进行肌电图检查以辅助诊断。
结果
发现代谢综合征患者的神经病变患病率高于对照组。（A组、B组、C组、健康对照组分别为9.9%；16.65%；23.31%；3.3%）（A组p = 0.003，B组p = 0.0002，C组p = 0.0002）。C组中甘油三酯水平与神经病变之间存在关联。
结论
MS患者可能比我们估计的有更多的神经病变风险。
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