Otelea Marina Ruxandra, Nartea Roxana, Popescu Florina Georgeta, Covaleov Anatoli, Mitoiu Brindusa Ilinca, Nica Adriana Sarah
Clinical Department 5, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Clinical Department 9, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Curr Issues Mol Biol. 2022 Jun 8;44(6):2646-2663. doi: 10.3390/cimb44060181.
An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and inflammation, and is a major risk factor for diabetes and cardiovascular diseases. Taking these elements into consideration, we conducted an extensive literature revision of the subject, considering as ectopic fat-related mechanisms the following: (a) the direct compression and the association with the metabolic syndrome of the fat deposition around the wrist, (b) the insulin resistance, dyslipidemia, inflammatory, and oxidative mechanisms related to the central deposition of the fat, (c) the impaired muscle contraction and metabolism related to myosteatosis. Each section presents the cellular pathways which are modified by the ectopic deposition of the adipose tissue and the impact in the pathogeny of the carpal tunnel syndrome. In conclusion, the experimental and clinical data support the epidemiological findings. Efforts to reduce the obesity epidemics will improve not only cardio-metabolic health but will reduce the burden of the disability-free life expectancy due to the carpal tunnel syndrome.
许多流行病学研究发现肥胖与腕管综合征之间存在关联。因此，有必要评估可能解释这两种疾病之间关联的生理病理联系。异位脂肪组织会引发代谢综合征和炎症，是糖尿病和心血管疾病的主要危险因素。考虑到这些因素，我们对该主题进行了广泛的文献综述，将以下内容视为与异位脂肪相关的机制：（a）手腕周围脂肪沉积的直接压迫以及与代谢综合征的关联；（b）与脂肪中心沉积相关的胰岛素抵抗、血脂异常、炎症和氧化机制；（c）与肌脂肪变性相关的肌肉收缩和代谢受损。每个部分都介绍了因脂肪组织异位沉积而改变的细胞途径以及对腕管综合征发病机制的影响。总之，实验和临床数据支持了流行病学研究结果。努力减少肥胖流行不仅将改善心脏代谢健康，还将减轻因腕管综合征导致的无残疾预期寿命负担。
