中国山东省沿海地区近二十年全民食盐加碘后非毒性结节性甲状腺肿的患病率

PREVALENCE OF NONTOXIC NODULAR GOITER AFTER A NEARLY TWO-DECADE UNIVERSAL SALT IODIZATION IN A LITTORAL REGION OF SHANDONG PROVINCE, CHINA.

作者信息

Shao H J, Li J, He X Q, Liu N, Li Y H, Yan J J, Qu X L, Yuan X Y

机构信息

Weihai Municipal Hospital affiliated to Dalian Medical University, Department of Clinical Lab, Shandong, PR China.

Weihai Municipal Hospital affiliated to Dalian Medical University, Department of Ultrasonography, Weihai, Shandong, PR China.

出版信息

Acta Endocrinol (Buchar). 2016 Jan-Mar;12(1):43-46. doi: 10.4183/aeb.2016.43.

DOI:10.4183/aeb.2016.43

PMID:31258799

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6586744/

Abstract

INTRODUCTION

With the introduction of iodized salt, more and more people are exposed to iodine sufficiency in some regions. The purpose of this study was to investigate the prevalence of nontoxic nodular goiter (NTNG) in the littoral region with high iodine supply after a nearly two- decade universal salt iodization.

SUBJECTS AND METHODS

Eight hundred and thirty- five participants (from 25~65 years; males 421 and females 414) were invited for the study from Huan-cui District of Weihai City, Shandong Province from January 2013 to September 2014. All participants were inspected and diagnosed by endocrinologists according to the thyroid function tests and the thyroid gland imaging. After the normal diet of three days, the urine samples of the participants were collected between 8:00AM and 9:00AM and the urinary iodine (UI) concentrations were analyzed using Urinary Iodide Test Kit.

RESULTS

The overall prevalence of NTNG in the region was 40.1%, and different prevalence occurred in the different age ranges (p<0.01). The prevalence of NTNG was 32.51%, 37.44%, 49.70%, 58.57 and 74.77% in the age group of ≤ 30, 31-40, 41-50, 51-60 and >60 years, respectively. Meanwhile, the prevalence of NTNG in women (42.08%) was higher than that in men (34.29%, p<0.05). The median of UI concentrations were 139.4μg/L and 101.5μg/L for the group with NTNG and without NTNG, respectively (p<0.01). However, there was no significant difference in UI concentrations among the groups with different age ranges (p>0.05), and statistical difference was not observed for UI concentrations between women and men (p>0.05). Intriguingly, higher UI concentrations were found in the group with larger thyroid size (p<0.01).

CONCLUSION

The iodine excess can lead to the high occurrence of nodular goiter in the littoral region, and individual UI concentration detection is recommended for the iodine nutritional status analysis among normal people when Universal Salt Iodization (USI) continues to be implemented in the region.

摘要

引言

随着碘盐的推广，一些地区越来越多的人处于碘充足状态。本研究旨在调查在近二十年全民食盐加碘后，高碘供应沿海地区非毒性结节性甲状腺肿（NTNG）的患病率。

对象与方法

2013年1月至2014年9月，从山东省威海市环翠区邀请了835名参与者（年龄在25至65岁之间；男性421名，女性414名）参与研究。所有参与者均由内分泌科医生根据甲状腺功能测试和甲状腺成像进行检查和诊断。在正常饮食三天后，于上午8:00至9:00收集参与者的尿液样本，并使用尿碘检测试剂盒分析尿碘（UI）浓度。

结果

该地区NTNG的总体患病率为40.1%，不同年龄范围的患病率不同（p<0.01）。≤30岁、31 - 40岁、41 - 50岁、51 - 60岁和>60岁年龄组的NTNG患病率分别为32.51%、37.44%、49.70%、58.57%和74.77%。同时，女性NTNG的患病率（42.08%）高于男性（34.29%，p<0.05）。NTNG组和非NTNG组的尿碘浓度中位数分别为139.4μg/L和101.5μg/L（p<0.01）。然而，不同年龄范围组之间的尿碘浓度无显著差异（p>0.05），男女之间的尿碘浓度也未观察到统计学差异（p>0.05）。有趣的是，甲状腺体积较大的组尿碘浓度较高（p<0.01）。