Ricaurte G A, DeLanney L E, Finnegan K T, Irwin I, Langston J W
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Brain Res. 1988 Jan 12;438(1-2):395-8. doi: 10.1016/0006-8993(88)91371-6.
The dopamine-depleting effects of intracerebroventricularly administered 6-hydroxydopamine (6-OHDA) were studied in young mature (6-8 weeks), older (8-12 months) and aged (18-24 months) mice. No differences were noted between age groups. To rule out the possibility that higher levels of monoamine oxidase (which degrades 6-OHDA) in older animals might be masking an increased sensitivity of older neurons to 6-OHDA, experiments were repeated after treatment with pargyline (50 mg/kg). Again, no differences between age groups were noted. We conclude that aging does not increase the sensitivity of dopaminergic neurons to 6-OHDA.
研究了脑室内注射6-羟基多巴胺（6-OHDA）对年轻成熟（6-8周）、年长（8-12个月）和老年（18-24个月）小鼠的多巴胺耗竭作用。各年龄组之间未观察到差异。为排除老年动物中较高水平的单胺氧化酶（可降解6-OHDA）可能掩盖老年神经元对6-OHDA敏感性增加的可能性，在用帕吉林（50mg/kg）治疗后重复实验。同样，各年龄组之间未观察到差异。我们得出结论，衰老不会增加多巴胺能神经元对6-OHDA的敏感性。
