• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence.

作者信息

Cadet J L, Katz M, Jackson-Lewis V, Fahn S

机构信息

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

出版信息

Brain Res. 1989 Jan 2;476(1):10-5. doi: 10.1016/0006-8993(89)91530-8.

DOI:10.1016/0006-8993(89)91530-8
PMID:2492442
Abstract

Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either D-alpha-tocopherol or all-racemic-alpha-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the free radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

摘要

相似文献

1
Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence.
Brain Res. 1989 Jan 2;476(1):10-5. doi: 10.1016/0006-8993(89)91530-8.
2
Methylprednisolone treatments alter apomorphine-induced circling in the rat model of 6-hydroxydopamine-induced striatal denervation.甲基强的松龙治疗可改变6-羟基多巴胺诱导的纹状体去神经大鼠模型中阿扑吗啡诱导的旋转行为。
Int J Neurosci. 1989 Jan;44(1-2):149-54. doi: 10.3109/00207458908986191.
3
Atrophy of the striatum and motor disturbance induced by colchicine.秋水仙碱诱导的纹状体萎缩和运动障碍。
Brain Res. 1987 Sep 22;421(1-2):353-7. doi: 10.1016/0006-8993(87)91306-0.
4
A two-population model of rat rotational behavior: effects of unilateral nigrostriatal 6-hydroxydopamine on striatal neurochemistry and amphetamine-induced rotation.大鼠旋转行为的双群体模型：单侧黑质纹状体6-羟基多巴胺对纹状体神经化学及苯丙胺诱导旋转的影响
Brain Res. 1987 Nov 24;426(2):323-31. doi: 10.1016/0006-8993(87)90885-7.
5
Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence.假手术移植可预防6-羟基多巴胺诱导的大鼠多巴胺能毒性：行为学和形态学证据。
Brain Res. 1991 Jun 7;550(2):231-8. doi: 10.1016/0006-8993(91)91323-s.
6
Does contralateral circling involve action of drugs on hyposensitive striatal dopamine receptors in the hemisphere contralateral to denervation?对侧旋转是否涉及药物对去神经支配对侧半球中低敏纹状体多巴胺受体的作用？
Neuropharmacology. 1983 Mar;22(3):295-302. doi: 10.1016/0028-3908(83)90243-5.
7
Behavioral alterations after unilateral 6-hydroxydopamine lesions of the striatum. Effect of alpha-tocopherol.纹状体单侧6-羟基多巴胺损伤后的行为改变。α-生育酚的作用。
Pol J Pharmacol. 2001 Sep-Oct;53(5):435-48.
8
Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons and in striatal dopamine content in rats with intrastriatal injection of 6-hydroxydopamine.环孢菌素A可减轻纹状体内注射6-羟基多巴胺的大鼠黑质纹状体多巴胺能神经元中酪氨酸羟化酶免疫反应性及纹状体多巴胺含量的降低。
Exp Neurol. 1997 Aug;146(2):526-35. doi: 10.1006/exnr.1997.6575.
9
Two kinds of nigrostriatal asymmetry: relationship to dopaminergic drug sensitivity and 6-hydroxydopamine lesion effects in Long-Evans rats.两种黑质纹状体不对称性：与多巴胺能药物敏感性及6-羟基多巴胺损伤效应在Long-Evans大鼠中的关系
Brain Res. 1988 May 31;450(1-2):334-41. doi: 10.1016/0006-8993(88)91572-7.
10
Sparing of behavior and basal extracellular dopamine after 6-hydroxydopamine lesions of the nigrostriatal pathway in rats exposed to a prelesion sensitizing regimen of amphetamine.在接受安非他明损伤前致敏方案的大鼠中，黑质纹状体通路经6-羟基多巴胺损伤后行为和基础细胞外多巴胺的保留情况。
Exp Neurol. 2004 Sep;189(1):78-93. doi: 10.1016/j.expneurol.2004.05.012.

引用本文的文献

1
Exploration of the Role of Vitamins in Preventing Neurodegenerative Diseases: Comprehensive Review on Preclinical and Clinical Findings.维生素在预防神经退行性疾病中的作用探索：临床前和临床研究结果的综合综述
Curr Neuropharmacol. 2025;23(5):547-563. doi: 10.2174/011570159X327677240902105443.
2
Vitamin E intake and multiple health outcomes: an umbrella review.维生素E摄入量与多种健康结局：一项汇总分析。
Front Public Health. 2023 Jul 13;11:1035674. doi: 10.3389/fpubh.2023.1035674. eCollection 2023.
3
Evidence for Oxidative Pathways in the Pathogenesis of PD: Are Antioxidants Candidate Drugs to Ameliorate Disease Progression?
氧化途径在 PD 发病机制中的证据：抗氧化剂是改善疾病进展的候选药物吗？
Int J Mol Sci. 2022 Jun 22;23(13):6923. doi: 10.3390/ijms23136923.
4
Dietary Antioxidants and Risk of Parkinson's Disease: A Systematic Review and Dose-Response Meta-analysis of Observational Studies.饮食抗氧化剂与帕金森病风险的关系：观察性研究的系统评价和剂量反应荟萃分析。
Adv Nutr. 2022 Oct 2;13(5):1493-1504. doi: 10.1093/advances/nmac001.
5
The Role of Vitamins in Neurodegenerative Disease: An Update.维生素在神经退行性疾病中的作用：最新进展
Biomedicines. 2021 Sep 22;9(10):1284. doi: 10.3390/biomedicines9101284.
6
Benefits of Vitamins in the Treatment of Parkinson's Disease.维生素在帕金森病治疗中的益处。
Oxid Med Cell Longev. 2019 Feb 20;2019:9426867. doi: 10.1155/2019/9426867. eCollection 2019.
7
How do we fit ferroptosis in the family of regulated cell death?铁死亡如何融入调控性细胞死亡家族？
Cell Death Differ. 2017 Dec;24(12):1991-1998. doi: 10.1038/cdd.2017.149. Epub 2017 Oct 6.
8
A historic study that opened a new chapter in nutritional science.一项开启营养科学新篇章的历史性研究。
Acta Pharmacol Sin. 2016 Dec;37(12):1641-1644. doi: 10.1038/aps.2016.131. Epub 2016 Nov 21.
9
Beneficial Effect of Vitamin E in Rotenone Induced Model of PD: Behavioural, Neurochemical and Biochemical Study.维生素 E 对鱼藤酮诱导的 PD 模型的有益作用：行为、神经化学和生化研究。
Exp Neurobiol. 2013 Sep;22(3):214-23. doi: 10.5607/en.2013.22.3.214. Epub 2013 Sep 30.
10
Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model.荜澄茄酮[4-(4-羟基-3-甲氧基苯基)-2-丁酮]和丁香酚[2-甲氧基-4-(2-丙烯基)苯酚]对 6-羟多巴胺诱导的帕金森病小鼠模型中病理进程的影响。
Neurochem Res. 2011 Dec;36(12):2244-9. doi: 10.1007/s11064-011-0548-5. Epub 2011 Jul 19.