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IL-6Ra in Smooth Muscle Cells Protects against - and Hypoxia-induced Pulmonary Hypertension.

作者信息

Mickael Claudia, Kumar Rahul, Hernandez-Saavedra Daniel, Kassa Biruk, Sanders Linda, Koyanagi Dan, Gu Sue, Lee Michael H, Tuder Rubin M, Graham Brian B

机构信息

1 University of Colorado Anschutz Medical Campus Aurora, Colorado.

出版信息

Am J Respir Cell Mol Biol. 2019 Jul;61(1):123-126. doi: 10.1165/rcmb.2018-0277LE.

Abstract
摘要

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Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension.
J Clin Invest. 2018 May 1;128(5):1956-1970. doi: 10.1172/JCI96462. Epub 2018 Apr 9.
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Clinical trial protocol for TRANSFORM-UK: A therapeutic open-label study of tocilizumab in the treatment of pulmonary arterial hypertension.
Pulm Circ. 2018 Jan-Mar;8(1):2045893217735820. doi: 10.1177/2045893217735820. Epub 2017 Sep 28.
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The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.
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Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.
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