Persson M P, Nilsson A, Hartvig P
Uppsala, Sweden Hospital Pharmacy, University Hospital.
Clin Pharmacol Ther. 1988 Mar;43(3):324-31. doi: 10.1038/clpt.1988.39.
The kinetics and dynamics of midazolam were investigated in 20 female patients undergoing lower abdominal surgery. The relation between the plasma concentrations of midazolam and pharmacokinetic end points was evaluated after an intravenous infusion regimen in 10 patients given an epidural anesthetic. The remaining 10 patients were anesthetized with a totally intravenous anesthetic technique with midazolam and alfentanil. The effect was assessed by means of a rating scale divided into degree of sedation and amnesia. A good correlation was found between plasma level of midazolam and pharmacodynamic response. The relation between the quantal response data and the plasma concentration was represented by an s-shaped concentration-effect curve. Despite similar kinetics of midazolam in the two groups, the postoperative drowsiness was more pronounced in the group receiving total intravenous anesthesia. The concomitant administration of alfentanil shifted the concentration-effect curve regarding sedation to the left.
在20名接受下腹部手术的女性患者中研究了咪达唑仑的动力学和动态变化。在10名接受硬膜外麻醉的患者中，采用静脉输注方案后，评估了咪达唑仑血浆浓度与药代动力学终点之间的关系。其余10名患者采用咪达唑仑和阿芬太尼全静脉麻醉技术进行麻醉。通过分为镇静程度和遗忘程度的评分量表评估效果。发现咪达唑仑血浆水平与药效学反应之间存在良好的相关性。定量反应数据与血浆浓度之间的关系由s形浓度-效应曲线表示。尽管两组中咪达唑仑的动力学相似，但在接受全静脉麻醉的组中，术后嗜睡更为明显。阿芬太尼的联合使用使关于镇静的浓度-效应曲线向左移动。
