Kowaluk E A, Poliszczuk R, Fung H L
Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo 14260.
Eur J Pharmacol. 1987 Dec 15;144(3):379-83. doi: 10.1016/0014-2999(87)90392-x.
Tolerance and cross-tolerance to the relaxant effects of S-nitroso-N-acetylpenicillamine (SNAP) and nitroglycerin were examined in rat aortic rings. Nitroglycerin-tolerant rings remained fully responsive to SNAP and sodium nitroprusside. Thus, reduced metabolic activation of nitroglycerin, rather than impaired guanylate cyclase activity, appeared to be the operating mechanism for nitrate tolerance in this preparation. Under similar conditions, SNAP incubation induced less tolerance than nitroglycerin. S-nitrosothiols, therefore, appear to be less tolerance-producing than nitroglycerin.
