Prusek W, Astaldi G
Arch Immunol Ther Exp (Warsz). 1979;27(1-2):59-71.
The effect of in vitro irradiation with increasing in logarythmic progress X-ray doses on lymphocyte viability and on T and B lymphocyte populations was studied in normal adults, patients with myasthenia gravis and in patients undergoing long-term steroid therapy. Decrease in numbers of lymphocytes carrying T or B lymphocyte surface markers was higher than viable cell loss. The decrease showed no linear correlation with X-ray doses applied, which might reflect the existence of radioresistant T and B lymphocytes. A higher so called early radiosensitivity of B lymphocytes was demonstrated. In patients with myasthenia gravis early radioresistance of T lymphocytes was detected. In patients undergoing long-term steroid therapy, an increase in numbers of cells lacking markers of any of lymphocyte populations was found in parallel with a decrease in T lymphocyte number which, in these patients, showed a higher radiosensitivity.
在正常成年人、重症肌无力患者以及接受长期类固醇治疗的患者中，研究了以对数递增的X射线剂量进行体外照射对淋巴细胞活力以及T和B淋巴细胞群体的影响。携带T或B淋巴细胞表面标志物的淋巴细胞数量减少幅度高于活细胞损失。这种减少与所施加的X射线剂量无线性相关性，这可能反映出存在抗辐射的T和B淋巴细胞。结果表明B淋巴细胞具有更高的所谓早期放射敏感性。在重症肌无力患者中检测到T淋巴细胞早期抗辐射。在接受长期类固醇治疗的患者中，发现缺乏任何淋巴细胞群体标志物的细胞数量增加，同时T淋巴细胞数量减少，在这些患者中T淋巴细胞表现出更高的放射敏感性。
