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A new insight into purinergic pharmacology: Three fungal species as natural P2X7R antagonists.

作者信息

Soares-Bezerra Rômulo José, da Silva Ferreira Natiele Carla, de Almeida Alves Tânia Maria, Zani Carlos Leomar, Rosa Luiz Henrique, Faria Robson Xavier, da Silva Frutuoso Válber, Alves Luiz Anastacio

机构信息

Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Laboratory of Chemistry of Bioactive Natural Products, René Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Brazil.

出版信息

Phytother Res. 2019 Sep;33(9):2319-2328. doi: 10.1002/ptr.6412. Epub 2019 Jul 2.

DOI:10.1002/ptr.6412
PMID:31264271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6771832/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/f9267657f4e1/PTR-33-2319-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/a01d5f179f46/PTR-33-2319-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/9b2edb3b7050/PTR-33-2319-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/381ae606c697/PTR-33-2319-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/81cc3bc23255/PTR-33-2319-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/f9267657f4e1/PTR-33-2319-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/a01d5f179f46/PTR-33-2319-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/9b2edb3b7050/PTR-33-2319-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/381ae606c697/PTR-33-2319-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/81cc3bc23255/PTR-33-2319-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de21/6771832/f9267657f4e1/PTR-33-2319-g005.jpg

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本文引用的文献

1
An Improved Method for P2X7R Antagonist Screening.一种改进的P2X7受体拮抗剂筛选方法。
PLoS One. 2015 May 19;10(5):e0123089. doi: 10.1371/journal.pone.0123089. eCollection 2015.
2
Peripheral P2X7 receptor-induced mechanical hyperalgesia is mediated by bradykinin.外周P2X7受体诱导的机械性痛觉过敏由缓激肽介导。
Neuroscience. 2014 Sep 26;277:163-73. doi: 10.1016/j.neuroscience.2014.06.057. Epub 2014 Jul 2.
3
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.P2X7 受体通道：最新进展及 P2X7 拮抗剂在疾病模型中的应用。
GC-MS Metabolomics profiling and HR-APCI-MS characterization of potential anticancer compounds and antimicrobial activities of extracts from Picrorhiza kurroa roots.
GC-MS 代谢组学分析和 HR-APCI-MS 鉴定，揭示藏黄连根提取物中的潜在抗癌化合物和抗菌活性。
J Appl Biomed. 2021 Mar;19(1):26-39. doi: 10.32725/jab.2020.017. Epub 2021 Jan 20.
Pharmacol Rev. 2014 Jul;66(3):638-75. doi: 10.1124/pr.113.008003.
4
The P2X7 receptor: shifting from a low- to a high-conductance channel - an enigmatic phenomenon?P2X7受体：从低电导通道向高电导通道的转变——一种神秘现象？
Biochim Biophys Acta. 2014 Oct;1838(10):2578-87. doi: 10.1016/j.bbamem.2014.05.015. Epub 2014 May 21.
5
P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage.P2X7受体抑制可阻断幼鼠癫痫发作的进展并减轻海马损伤。
CNS Neurosci Ther. 2014 Jun;20(6):556-64. doi: 10.1111/cns.12272. Epub 2014 Apr 21.
6
The diversity, extracellular enzymatic activities and photoprotective compounds of yeasts isolated in Antarctica.南极酵母的多样性、细胞外酶活性和光保护化合物。
Braz J Microbiol. 2011 Jul;42(3):937-47. doi: 10.1590/S1517-838220110003000012. Epub 2011 Sep 1.
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P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1 pathway.P2X7阻断通过抑制NLRP3/ASC/半胱天冬酶1途径的激活来减轻小鼠狼疮性肾炎。
Arthritis Rheum. 2013 Dec;65(12):3176-85. doi: 10.1002/art.38174.
8
Activation and regulation of the inflammasomes.炎症小体的激活与调控。
Nat Rev Immunol. 2013 Jun;13(6):397-411. doi: 10.1038/nri3452.
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Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica.与南极特有和适应寒冷的大型藻类相关的真菌群落的多样性和生物勘探。
ISME J. 2013 Jul;7(7):1434-51. doi: 10.1038/ismej.2013.77. Epub 2013 May 23.
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Cell Death Dis. 2012 Oct 11;3(10):e403. doi: 10.1038/cddis.2012.144.