Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Nat Prod Res. 2020 Nov;34(21):3108-3116. doi: 10.1080/14786419.2019.1610753. Epub 2019 Jul 2.
Two new cembrane diterpenoids, named populeuphrines A and B ( and ), together with three known analogues (-) were isolated from the resins of . The planar structures and relative configurations of and were elucidated by detailed 1 D and 2 D NMR spectroscopic analyses. The absolute configurations of and were determined by X-ray diffraction analysis and quantum chemical computation. Biological activities of all the isolates against proliferation of human cancer cells and umbilical cord mesenchymal stem cells were evaluated.
从 树脂中分离得到两个新的海松烷二萜类化合物，命名为 populeuphrines A 和 B（和），以及三个已知类似物（-）。通过详细的 1D 和 2D NMR 光谱分析阐明了和的平面结构和相对构型。和的绝对构型通过 X 射线衍射分析和量子化学计算确定。评估了所有分离物对人癌细胞和脐带间充质干细胞增殖的抑制活性。
