Troncone L R, Ferreira T M, Braz S, Silveira Filho N G, Tufik S
Departamento de Psicobiologia, Escola Paulista de Medicina, São Paulo-SP, Brazil.
Psychopharmacology (Berl). 1988;94(1):79-83. doi: 10.1007/BF00735885.
REM sleep deprivation (REMSD) induces augmented responses to dopaminergic agonists. Prolonged administration of neuroleptics induces a similar state, probably by the production of supersensitivity of dopaminergic receptors. Such a supersensitive state could be induced by REMSD as a result of impairment of dopamine neurotransmission. In order to test this hypothesis, bromocriptine, nomifensine, amphetamine, L-dopa, imipramine and electroconvulsive shock (ECS) were administered to rats during REMSD, and aggressive and stereotyped behaviors were measured. Amphetamine and L-dopa pretreatment attenuated the increases in apomorphine-induced stereotypy and aggression in REMSD rats, but ECS selectively reduced apomorphine-induced aggression. The other drugs tested were ineffective on both behavioral tests. Such a selective action may reflect different effects of ECS on different dopaminergic systems such as those involved with stereotypy and aggression. The results suggest that REMSD induces an increase in dopaminergic sensitivity which may be reversed by pretreatment with some dopaminergic agonists.
快速眼动睡眠剥夺（REMSD）会导致对多巴胺能激动剂的反应增强。长期使用抗精神病药物会引发类似状态，可能是通过产生多巴胺能受体超敏反应实现的。这种超敏状态可能是由于多巴胺神经传递受损，由快速眼动睡眠剥夺所诱发。为了验证这一假设，在快速眼动睡眠剥夺期间，给大鼠注射溴隐亭、诺米芬辛、苯丙胺、左旋多巴、丙咪嗪和电休克（ECS），并测量攻击行为和刻板行为。苯丙胺和左旋多巴预处理减弱了快速眼动睡眠剥夺大鼠中阿扑吗啡诱导的刻板行为和攻击行为的增加，但电休克选择性地降低了阿扑吗啡诱导的攻击行为。所测试的其他药物在这两种行为测试中均无效。这种选择性作用可能反映了电休克对不同多巴胺能系统（如与刻板行为和攻击行为相关的系统）的不同影响。结果表明，快速眼动睡眠剥夺会导致多巴胺能敏感性增加，而用一些多巴胺能激动剂进行预处理可能会使其逆转。
