Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Trends Plant Sci. 2019 Aug;24(8):688-699. doi: 10.1016/j.tplants.2019.05.005. Epub 2019 Jun 29.
Gene clustering is rare in eukaryotes. However, nucleotide-binding leucine-rich repeat (NLR)-encoding disease resistance (R) genes show consistent clustering in plant genomes. These arrangements are likely to provide coregulatory benefits, as suggested by growing evidence that the gene products of both paired and larger clusters of NLRs act together in triggering immunity. Head-to-head gene pairs where one of the encoded NLRs includes an integrated decoy domain appear to behave differently than clusters evolved from closely related typical NLRs. These patterns may help to explain the broad resistance that most plants have despite their finite number of R genes. By taking into consideration the relationship between genomic arrangement and function, we can improve our understanding of and ability to predict plant immune detection.
基因聚类在真核生物中很少见。然而，核苷酸结合富含亮氨酸重复（NLR）编码的疾病抗性（R）基因在植物基因组中表现出一致的聚类。这些排列可能提供了核心调控的好处，越来越多的证据表明，配对和更大的 NLR 簇的基因产物在触发免疫方面协同作用。一个编码的 NLR 中包含一个集成的诱饵结构域的头对头基因对似乎与从密切相关的典型 NLR 进化而来的簇表现不同。这些模式可能有助于解释尽管大多数植物的 R 基因数量有限，但它们仍具有广泛的抗性。通过考虑基因组排列和功能之间的关系，我们可以提高对植物免疫检测的理解和预测能力。
