中国地钱中的香叶木基二苯并呋喃及其诱导线粒体衍生细胞 PARAPTOSIS 毒性活性
Prenylated Bibenzyls from the Chinese Liverwort and Their Mitochondria-Derived Paraptotic Cytotoxic Activities.
机构信息
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education , Shandong University , Jinan 250012 , People's Republic of China.
School of Chemistry and Chemical Engineering , Shandong University , Jinan 250010 , People's Republic of China.
出版信息
J Nat Prod. 2019 Jul 26;82(7):1741-1751. doi: 10.1021/acs.jnatprod.8b00897. Epub 2019 Jul 3.
Nine new prenylated bibenzyls, radstrictins A-I (-), and 11 known congeners were obtained from the Chinese liverwort . Their structures were identified by analysis of HRMS, NMR, and electronic circular dichroism data. Radstrictins A-F (-) were isolated as a racemate or scalemic mixtures. All the isolated compounds were subjected to cytotoxicity assessment. Methyl 2,4-dihydroxy-3-(3-methyl-2-butenyl)-6-phenethylbenzoate () exhibited significant activity against human lung cancer cell lines A549 and NCI-H1299 with IC values of 6.0 and 5.1 μM, respectively. Further research revealed that cell death triggered by occurred via mitochondria-derived paraptosis.
从中国产的地钱属植物中分离得到了 9 个新的苯并二氢呋喃类化合物，分别命名为 radstrictins A-I（-），并对 11 个已知的同系物进行了结构鉴定。通过 HRMS、NMR 和电子圆二色谱数据分析确定了其结构。Radstrictins A-F（-）是作为外消旋混合物或对映体混合物分离得到的。对所有分离得到的化合物进行了细胞毒性评估。化合物 2,4-二羟基-3-(3-甲基-2-丁烯基)-6-苯乙基苯甲酸甲酯（）对人肺癌细胞系 A549 和 NCI-H1299 表现出显著的抑制活性，IC 值分别为 6.0 和 5.1 μM。进一步的研究表明，化合物 导致的细胞死亡是通过线粒体来源的paraptosis 途径触发的。
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