Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Independent Laboratory of Natural Products Chemistry, Department of Pharmacognosy, Medical University of Lublin, 1 Chodzki Street, 20-093 Lublin, Poland.
J Nat Prod. 2020 Mar 27;83(3):756-769. doi: 10.1021/acs.jnatprod.9b01132. Epub 2020 Mar 6.
Plants of the genus are chemically very distinct from the other liverworts since they mainly elaborate bibenzyls including bibenzyl cannabinoids and prenyl bibenzyl derivatives, as well as bis-bibenzyls. Several of these components show biological activities such as psychoactivity, vasopressin antagonist, antimicrobial, antifungal, and NO production inhibitory activity, and cytotoxic activity against human cancer cell lines. While distribution of terpenoids in species is in general very limited, some Portuguese species are rich sources of sesquiterpenoids. Among 679 liverwort species so far examined chemically, 264 species contained α-tocopherol, which may play an important antioxidative role for the constituents of oil bodies of liverworts.
该属植物在化学上与其他苔类植物有很大的不同，因为它们主要产生联苄类化合物，包括联苄大麻素和prenyl 联苄衍生物，以及双联苄类化合物。这些成分中的一些具有生物活性，如精神活性、抗血管加压素、抗菌、抗真菌和抑制一氧化氮生成活性，以及对人癌细胞系的细胞毒性活性。虽然萜类化合物在该属中的分布通常非常有限，但一些葡萄牙物种是倍半萜类化合物的丰富来源。在迄今为止化学分析的 679 种苔类植物中，有 264 种含有α-生育酚，这可能对苔类植物油体的成分起到重要的抗氧化作用。
