长非编码 RNA 与核仁中的应激反应。

Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., 123182 Moscow, Russia.

Cells. 2019 Jul 2;8(7):668. doi: 10.3390/cells8070668.

Long noncoding RNAs (lncRNAs) perform diverse functions in the regulation of cellular processes. Here we consider a variety of lncRNAs found in the ribosome production center, the nucleolus, and focus on their role in the response to environmental stressors. Nucleolar lncRNAs ensure stress adaptation by cessation of resource-intensive ribosomal RNA (rRNA) synthesis and by inducing the massive sequestration of proteins within the nucleolus. Different cell states like quiescence and cancer are also controlled by specific lncRNAs in the nucleolus. Taken together, recent findings allow us to consider lncRNAs as multifunctional regulators of nucleolar activities, which are responsive to various physiological conditions.

长非编码 RNA（lncRNA）在细胞过程的调控中发挥着多样化的功能。在这里，我们考虑了在核糖体产生中心（核仁）中发现的各种 lncRNA，并专注于它们在应对环境胁迫因子中的作用。核仁 lncRNA 通过停止资源密集型核糖体 RNA（rRNA）合成并诱导大量蛋白质在核仁内隔离，从而确保了应激适应。核仁中的特定 lncRNA 也控制着不同的细胞状态，如静止和癌症。总之，最近的研究结果使我们能够将 lncRNA 视为核仁活性的多功能调节剂，它们对各种生理条件做出响应。