应激诱导核仁进化：核糖体基因间间隔区(rIGS)转录本的作用。

Stress-Induced Evolution of the Nucleolus: The Role of Ribosomal Intergenic Spacer (rIGS) Transcripts.

机构信息

Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.

Moscow Center for Advanced Studies, Moscow 123592, Russia.

出版信息

Biomolecules. 2024 Oct 20;14(10):1333. doi: 10.3390/biom14101333.

DOI:10.3390/biom14101333

PMID:39456266

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11505599/

Abstract

It became clear more than 20 years ago that the nucleolus not only performs the most important biological function of assembling ribonucleic particles but is also a key controller of many cellular processes, participating in cellular adaptation to stress. The nucleolus's multifunctionality is due to the peculiarities of its biogenesis. The nucleolus is a multilayered biomolecular condensate formed by liquid-liquid phase separation (LLPS). In this review, we focus on changes occurring in the nucleolus during cellular stress, molecular features of the nucleolar response to abnormal and stressful conditions, and the role of long non-coding RNAs transcribed from the intergenic spacer region of ribosomal DNA (IGS rDNA).

摘要

二十多年前，人们已经清楚地认识到核仁不仅具有组装核糖核蛋白颗粒的最重要的生物学功能，而且还是许多细胞过程的关键控制器，参与细胞对压力的适应。核仁的多功能性归因于其生物发生的特殊性。核仁是由液-液相分离（LLPS）形成的多层生物分子凝聚物。在这篇综述中，我们重点关注细胞应激过程中核仁发生的变化、核仁对异常和应激条件的反应的分子特征，以及转录自核糖体 DNA（IGS rDNA）基因间区的长非编码 RNA 的作用。