Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
Nutrients. 2019 Jul 2;11(7):1509. doi: 10.3390/nu11071509.
Linn, commonly known as graviola, is one of the most popular plants used in Brazil for weight loss. The aim of this study is to evaluate the therapeutic effects of three different doses (50 mg/kg, 100 mg/kg, and 150 mg/kg) of aqueous graviola leaf extract (AGE) supplemented by oral gavage, on obese C57BL/6 mice. Food intake, body weight, an oral glucose tolerance test (OGTT), an insulin sensitivity test, quantification of adipose tissue cytokines, weight of fat pads, and serum biochemical and histological analyses of the liver, pancreas, and epididymal adipose tissue were measured. AGE had an anti-inflammatory effect by increasing IL-10 at doses of 50 and 100 mg/kg. Regarding the cholesterol profile, there was a significant decrease in LDL-cholesterol levels in the AGE 150 group, and VLDL-cholesterol and triglycerides in the AGE 100 and 150 groups. There was an increase in HDL cholesterol in the AGE 150 group. The extract was able to reduce the adipocyte area of the epididymal adipose tissue in the AGE 100 and 150 groups. According to the histological analysis of the liver and pancreas, no significant difference was found among the groups. There were no significant effects of AGE on OGTT and serum fasting glucose concentration. However, the extract was effective in improving glucose tolerance in the AGE 150 group.
Linn，通常被称为圣罗勒，是巴西用于减肥的最受欢迎的植物之一。本研究的目的是评估三种不同剂量（50mg/kg、100mg/kg 和 150mg/kg）的 Linn 叶水提物（AGE）经口服灌胃补充对肥胖 C57BL/6 小鼠的治疗效果。测量了食物摄入量、体重、口服葡萄糖耐量试验（OGTT）、胰岛素敏感性试验、脂肪组织细胞因子的定量、脂肪垫重量以及血清生化和肝脏、胰腺和附睾脂肪组织的组织学分析。AGE 在 50 和 100mg/kg 剂量下通过增加 IL-10 具有抗炎作用。关于胆固醇谱，AGE150 组 LDL-胆固醇水平显著降低，AGE100 和 150 组 VLDL-胆固醇和甘油三酯水平降低。AGE150 组 HDL 胆固醇水平升高。提取物能够减少附睾脂肪组织中脂肪细胞的面积在 AGE100 和 150 组中。根据肝和胰腺的组织学分析，各组之间没有发现显著差异。AGE 对 OGTT 和血清空腹血糖浓度没有显著影响。然而，提取物在 AGE150 组中有效改善了葡萄糖耐量。
