一个在生长、分化过程中以及细胞去极化后与c-fos共同调控的锌指编码基因。

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.

作者信息

Sukhatme V P, Cao X M, Chang L C, Tsai-Morris C H, Stamenkovich D, Ferreira P C, Cohen D R, Edwards S A, Shows T B, Curran T

机构信息

Department of Medicine, Howard Hughes Medical Institute, University of Chicago, Illinois 60637.

出版信息

Cell. 1988 Apr 8;53(1):37-43. doi: 10.1016/0092-8674(88)90485-0.

DOI:10.1016/0092-8674(88)90485-0

PMID:3127059

Abstract

Egr-1 is an early growth response gene that displays fos-like induction kinetics in fibroblasts, epithelial cells, and lymphocytes following mitogenic stimulation. Sequence analysis of murine Egr-1 cDNA predicts a protein with three DNA binding zinc fingers. The human EGR1 gene maps to chromosome 5 (bands 5q23-31). Egr-1 mRNA increases dramatically during cardiac and neural cell differentiation, and following membrane depolarization both in vitro and in vivo. Thus, Egr-1 and c-fos are often coregulated with strikingly similar kinetics. These results, in conjunction with the Egr-1 primary structure, suggest that Egr-1 may function as a transcriptional regulator in diverse biological processes.

摘要

Egr-1是一种早期生长反应基因，在有丝分裂原刺激后，成纤维细胞、上皮细胞和淋巴细胞中呈现出类似Fos的诱导动力学。对小鼠Egr-1 cDNA的序列分析预测其编码一种具有三个DNA结合锌指的蛋白质。人类EGR1基因定位于5号染色体（5q23 - 31带）。在心脏和神经细胞分化过程中，以及在体内外膜去极化后，Egr-1 mRNA会显著增加。因此，Egr-1和c-fos常常以极为相似的动力学共同被调节。这些结果，连同Egr-1的一级结构，表明Egr-1可能在多种生物学过程中作为转录调节因子发挥作用。