Alcorta E, Rubio J
Departamento de Genética, Universidad de Oviedo, Spain.
Heredity (Edinb). 1988 Feb;60 ( Pt 1):7-14. doi: 10.1038/hdy.1988.2.
Genetical study of olfactory response to ethyl alcohol (8 per cent) has been carried out on inbred lines extracted from a natural population using biometrical and chromosome analyses. A full diallel analysis was made in seven endogamic lines (3 high, 3 low and 1 intermediate in response values). Our results show a highly significant (P less than 0.001) additive component of variance and a less significant (P less than 0.05) directional dominance component suggesting overdominance and some endogamic depression. No significant maternal or reciprocal components of variation appear in our population. Two chromosome substitution assays among 3 inbred lines of extreme olfactory response add up information to the results of diallel analysis. The differences in response are due to chromosome III with an additive effect highly significant (P less than 0.001) in both studies. The other major chromosomes do not show any effect themselves but some interactions with chromosome III are significant. They can explain the directional dominance that we find in the diallel study. Analysed olfactory variation in response to ethanol can be considered as unspecific in relation to various chemical compounds.
利用生物统计学和染色体分析方法，对从自然种群中提取的近交系进行了对8%乙醇嗅觉反应的遗传学研究。对7个纯交系（反应值3个高、3个低和1个中等）进行了完全双列分析。我们的结果显示，方差的加性成分高度显著（P小于0.001），定向显性成分不太显著（P小于0.05），表明存在超显性和一些纯交衰退。在我们的种群中未出现显著的母体或互作变异成分。在3个嗅觉反应极端的近交系中进行的两次染色体替代试验为双列分析结果增添了信息。反应差异归因于Ⅲ号染色体，在两项研究中其加性效应均高度显著（P小于0.001）。其他主要染色体本身未显示任何效应，但与Ⅲ号染色体的一些互作显著。它们可以解释我们在双列研究中发现的定向显性。相对于各种化合物而言，所分析的对乙醇的嗅觉变异可被视为非特异性的。
