从 的根茎中分离得到一个新的佛手柑倍半萜。
A new bergamotane sesquiterpenoid from the rhizomes of var. .
机构信息
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, P. R. China.
Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P. R. China.
出版信息
Nat Prod Res. 2021 Feb;35(3):377-383. doi: 10.1080/14786419.2019.1633649. Epub 2019 Jul 5.
A new bergamotane-type sesquiterpene, named axanthiol A (), and six known compounds (-) were isolated from the rhizomes of var. . Their structures were established on the basis of extensive spectroscopic analysis and the absolute configuration of was confirmed by the Mosher ester method. Moreover, all the isolates were evaluated for their effects on LPS-induced nitric oxide (NO) production, and compound showed efficacious inhibitory activity with IC value of 34.81 μM.
从 var. 的根茎中分离得到了一种新的佛手柑烷型倍半萜，命名为 axanthiol A ()，并同时分离得到了 6 种已知化合物 (-)。基于广泛的光谱分析确定了它们的结构，并且通过 Mosher 酯法确定了 的绝对构型。此外，还评估了所有分离得到的化合物对 LPS 诱导的一氧化氮 (NO) 产生的影响，化合物 表现出有效的抑制活性，IC 值为 34.81 μM。
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