从豆蔻根茎中分离得到的四个新吡咯生物碱。
Four new pyrrole alkaloids from the rhizomes of Amomum koenigii.
机构信息
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, China.
School of Pharmacy, Xinxiang Medical University, Xinxiang, 453000, China.
出版信息
J Nat Med. 2021 Jan;75(1):173-177. doi: 10.1007/s11418-020-01461-2. Epub 2020 Oct 21.
Four new pyrrole alkaloids, named amokoens A-D (1-4), together with three known compounds (5-7) were isolated from the rhizomes of Amomum koenigii. Their structures and absolute configurations were established by spectroscopic data, including 1D and 2D NMR, and the optical rotation calculations. All the isolates were evaluated for their effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages. Compounds 1-7 inhibited NO production ranging from 27.1 to 82.4% at a concentration of 100 μM, and compounds 5 and 6 showed efficacious inhibitory activities with IC values of 42.2 and 69.3 µM, respectively.
从砂仁的根茎中分离得到了四个新的吡咯生物碱，分别命名为 amokoens A-D（1-4），以及三个已知化合物（5-7）。通过光谱数据，包括 1D 和 2D NMR 以及旋光计算，确定了它们的结构和绝对构型。所有分离物均评估了它们对脂多糖诱导的 RAW264.7 巨噬细胞中一氧化氮（NO）产生的影响。在 100 μM 的浓度下，化合物 1-7 的 NO 产量抑制率范围为 27.1%至 82.4%，化合物 5 和 6 表现出有效的抑制活性，IC 值分别为 42.2 和 69.3 µM。
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