Janeway C A
Fed Proc. 1979 Jun;38(7):2071-4.
Studies of the relationship between carrier-primed helper T cell dose and the antibody response to a hapten on that carrier reveal evidence for two synergistic T helper cells. One of these two T cells is absent in agammaglobulinemic mice. This finding is not due to suppression; instead, T helper cells from these mice interact synergistically with T helper cells from normal mice, as would be predicted if two populations of cells are present in normal mice, while only one is present in the agammaglobulinemic mice. These findings, taken together with studies in similar systems, suggest that one of the two T helper cells recognizes immunoglobulin on B cells, while the other is specific for carrier. It remains to be determined whether both cells show the phenomenon of major histocompatibility complex restriction, or whether this a property of one of the cells only. It is also not clear whether the Ig-recognizing T cell is also carrier specific, or whether its apparent carrier specificity in this system reflects an ability of the carrier to bring together Ig and an I region gene product into a unique configuration on the B cell surface.
对半抗原载体引发的辅助性T细胞剂量与该载体上半抗原抗体反应之间关系的研究揭示了两种协同辅助性T细胞的证据。这两种T细胞中的一种在无丙种球蛋白血症小鼠中不存在。这一发现并非由于抑制作用；相反，这些小鼠的辅助性T细胞与正常小鼠的辅助性T细胞协同相互作用，这正如如果正常小鼠中存在两种细胞群体，而无丙种球蛋白血症小鼠中仅存在一种细胞群体时所预测的那样。这些发现与类似系统中的研究结果相结合，表明两种辅助性T细胞中的一种识别B细胞上的免疫球蛋白，而另一种对载体具有特异性。两种细胞是否都表现出主要组织相容性复合体限制现象，或者这是否仅是其中一种细胞的特性，仍有待确定。同样不清楚识别Ig的T细胞是否也对载体具有特异性，或者其在该系统中明显的载体特异性是否反映了载体将Ig和I区基因产物聚集在B细胞表面独特构型中的能力。
