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1
Limiting dilution analysis of helper T-cell function.辅助性T细胞功能的有限稀释分析。
Immunology. 1975 Jun;28(6):1135-48.
2
Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.T细胞/B细胞协作的抗原特异性和非特异性介质。I. 不同T细胞产生这些介质的证据。
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3
Limiting dilution analysis of helper T-cell function. II. An approach to the study of the function of single helper T cells.辅助性T细胞功能的有限稀释分析。II. 单个辅助性T细胞功能研究的一种方法。
Immunology. 1976 Sep;31(3):343-52.
4
T cell dependence of B cell unresponsiveness in vitro.体外B细胞无反应性的T细胞依赖性
Eur J Immunol. 1974 Jun;4(6):410-6. doi: 10.1002/eji.1830040605.
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T cell-dependent mediator and B-cell clones.T细胞依赖性介质和B细胞克隆。
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6
Helper T cell interactions.辅助性T细胞相互作用。
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7
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Role of the major histocompatibility complex in T cell activation of B cell subpopulations: antigen-specific and H-2-restricted monoclonal TH cells activate Lyb-5+ B cells through an antigen-nonspecific and H-2-unrestricted effector pathway.主要组织相容性复合体在B细胞亚群T细胞活化中的作用：抗原特异性和H-2限制性单克隆TH细胞通过抗原非特异性和H-2非限制性效应途径激活Lyb-5+B细胞。
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9
Limiting dilution analysis of the suppressive effect mediated by alloantigen-primed cells.对同种抗原致敏细胞介导的抑制作用进行有限稀释分析。
Immunology. 1980 Oct;41(2):399-406.
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本文引用的文献

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Studies on mouse leukaemia. The role of the thymus in leukaemogenesis by cell-free leukaemic filtrates.小鼠白血病研究。胸腺在无细胞白血病滤液致白血病过程中的作用。
Br J Cancer. 1960 Mar;14(1):93-8. doi: 10.1038/bjc.1960.11.
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Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins.三硝基苯基-血蓝蛋白的免疫原性：一级和二级抗半抗原沉淀素的产生
J Immunol. 1966 Sep;97(3):421-30.
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Restriction of the capacity to respond to two antigens by single precursors of antibody-producing cells in culture.培养中产生抗体细胞的单个前体细胞对两种抗原应答能力的限制。
J Exp Med. 1969 Jan 1;129(1):141-52. doi: 10.1084/jem.129.1.141.
4
Cellular differentiation of the immune system of mice. I. Separate splenic antigen-sensitive units for different types of anti-sheep antibody-forming cells.小鼠免疫系统的细胞分化。I. 针对不同类型抗绵羊抗体形成细胞的脾脏抗原敏感单位。
J Exp Med. 1968 Sep 1;128(3):437-57. doi: 10.1084/jem.128.3.437.
5
Induction of a hemolysin response in vitro. Interaction of cells of bone marrow origin and thymic origin.体外溶血素反应的诱导。骨髓来源细胞与胸腺来源细胞的相互作用。
J Exp Med. 1970 Dec 1;132(6):1267-78. doi: 10.1084/jem.132.6.1267.
6
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
7
Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.体外免疫应答中的细胞相互作用。IV. 抗原特异性和同种异体胸腺衍生细胞因子作用的比较。
J Exp Med. 1972 Oct 1;136(4):722-36. doi: 10.1084/jem.136.4.722.
8
B cell activation in vivo by nonantigen-specific interaction with T cells. Frequency of immune responses increased by immunization with two antigens.B细胞通过与T细胞的非抗原特异性相互作用在体内被激活。用两种抗原进行免疫接种可提高免疫反应的频率。
J Exp Med. 1972 Aug 1;136(2):381-6. doi: 10.1084/jem.136.2.381.
9
Cell interactions in the immune response in vitro. 3. Specific collaboration across a cell impermeable membrane.体外免疫反应中的细胞相互作用。3. 跨细胞不可渗透膜的特异性协作。
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Immunological adjuvants and the mechanism of cell cooperation.免疫佐剂与细胞合作机制
J Exp Med. 1972 Jul 1;136(1):185-90. doi: 10.1084/jem.136.1.185.

辅助性T细胞功能的有限稀释分析。

Limiting dilution analysis of helper T-cell function.

作者信息

Waldmann H, Lefkovits I, Quintáns J

出版信息

Immunology. 1975 Jun;28(6):1135-48.

PMID:1079511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445909/
Abstract

Limiting dilution analysis has been applied to the study of T-cell 'helper' function in vitro. Using the microculture system one can estimate the numbers of (a) 'helper' T cells involved in specific collaboration with B cells and (b) those T cells which are able, on being activated by their specific antigen, to facilitate the response of B cells to another antigen. Such studies have enabled us to demonstrate that: (1) a single 'helper' T cell was able to activate a single B-cell precursor to detectable antibody production; (2) the 'helper' function of primed T cells was radio-resistant; (3) a minimal estimate of 'helper' frequencies could be obtained in defined cell populations; (4) nonspecific facilitation was directed towards virtually all available B cells of a given specificity if these were challenged with their appropriate particulate antigen; (5) the microculture system offers the opportunity to determine whether specific and non-specific T-cell 'helper' effects are a consequence of the activity of one T-cell type or of differenct subpopulations of T cells.

摘要

有限稀释分析已应用于体外T细胞“辅助”功能的研究。使用微量培养系统，可以估计：(a) 与B细胞进行特异性协作的“辅助”T细胞数量，以及(b) 那些被其特异性抗原激活后能够促进B细胞对另一种抗原作出反应的T细胞数量。此类研究使我们能够证明：(1) 单个“辅助”T细胞能够激活单个B细胞前体产生可检测到的抗体；(2) 致敏T细胞的“辅助”功能具有抗辐射性；(3) 在特定细胞群体中可以获得对“辅助”频率的最低估计；(4) 如果用适当的颗粒抗原刺激具有给定特异性的几乎所有可用B细胞，非特异性促进作用就会针对这些B细胞；(5) 微量培养系统提供了一个机会，来确定特异性和非特异性T细胞“辅助”效应是一种T细胞类型还是不同T细胞亚群活动的结果。