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1
Individual clones of carrier-specific T cells help idiotypically and isotypically heterogeneous anti-hapten B-cell responses.载体特异性T细胞的各个克隆以独特型和同种型异质性方式辅助抗半抗原B细胞应答。
Immunology. 1981 Jul;43(3):581-9.
2
Preventive effect of hapten-reactive thymus-derived helper lymphocytes on the tolerance induction in hapten-specific precursors of antibody-forming cells.半抗原反应性胸腺衍生辅助淋巴细胞对抗体形成细胞半抗原特异性前体细胞耐受性诱导的预防作用。
J Immunol. 1975 Jun;114(6):1771-8.
3
Role of the major histocompatibility complex in T cell activation of B cell subpopulations: antigen-specific and H-2-restricted monoclonal TH cells activate Lyb-5+ B cells through an antigen-nonspecific and H-2-unrestricted effector pathway.主要组织相容性复合体在B细胞亚群T细胞活化中的作用：抗原特异性和H-2限制性单克隆TH细胞通过抗原非特异性和H-2非限制性效应途径激活Lyb-5+B细胞。
J Immunol. 1982 Jul;129(1):267-71.
4
Idiotypic profile of the response to phosphorylcholine induced in the absence of the homologous antigen.在无同源抗原情况下诱导产生的对磷酸胆碱反应的独特型谱。
Eur J Immunol. 1980 Apr;10(4):299-304. doi: 10.1002/eji.1830100414.
5
Cell co-operation and hapten--carrier complexes.细胞合作与半抗原-载体复合物
Immunology. 1975 Oct;29(4):675-85.
6
Functional differentiation in the genetic control of murine T lymphocyte responses to human fibrinopeptide B.小鼠T淋巴细胞对人纤维蛋白肽B反应的遗传控制中的功能分化
J Immunol. 1983 Feb;130(2):637-43.
7
Clonal dominance and the preservation of clonal memory cells mediated by antigen-antibody.克隆优势以及由抗原-抗体介导的克隆记忆细胞的保存。
Immunology. 1976 Oct;31(4):541-51.
8
Functional analysis of GAT-specific T cell clones: H-2-restricted monoclonal T helper cells do not regulate expression of antibody isotypes.
J Immunol. 1982 Jul;129(1):217-21.
9
T cell-dependent hapten-specific and polyclonal B cell responses require release of interleukin 5.
J Immunol. 1988 Feb 1;140(3):705-12.
10
In vitro evidence from anti-hapten antibody responses for T helper and suppressor cells directed against major histocompatibility antigens in the mouse. Participation of I region determinants in the induction of T helper cells.小鼠中针对主要组织相容性抗原的T辅助细胞和抑制细胞的抗半抗原抗体反应的体外证据。I区决定簇在T辅助细胞诱导中的参与。
Eur J Immunol. 1979 Jul;9(7):561-9. doi: 10.1002/eji.1830090712.

引用本文的文献

1
Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways.主要组织相容性复合体在B细胞亚群T细胞活化中的作用。单一的单克隆辅助性T细胞群体通过不同途径激活不同的B细胞亚群。
J Exp Med. 1982 Aug 1;156(2):350-60. doi: 10.1084/jem.156.2.350.
2
Isotype specificity of helper T cell clones. Peyer's patch Th cells preferentially collaborate with mature IgA B cells for IgA responses.辅助性T细胞克隆的同种型特异性。派尔集合淋巴结的Th细胞优先与成熟的IgA B细胞协作以产生IgA应答。
J Exp Med. 1984 Mar 1;159(3):798-811. doi: 10.1084/jem.159.3.798.

本文引用的文献

1
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
Eur J Immunol. 1971 Jan;1(1):18-27. doi: 10.1002/eji.1830010104.
2
Clones of killer and helper T cells: growth requirements, specificity and retention of function in long-term culture.杀伤性T细胞和辅助性T细胞克隆：长期培养中的生长需求、特异性及功能维持
Immunol Rev. 1980;51:315-36. doi: 10.1111/j.1600-065x.1980.tb00326.x.
3
Idiotypic profile of the response to phosphorylcholine induced in the absence of the homologous antigen.在无同源抗原情况下诱导产生的对磷酸胆碱反应的独特型谱。
Eur J Immunol. 1980 Apr;10(4):299-304. doi: 10.1002/eji.1830100414.
4
Cell cooperation during in vivo anti-hapten antibody responses. V. Two synergistic Ly-1+23- helper T cells with distinctive specificities.体内抗半抗原抗体应答过程中的细胞协作。V. 两种具有独特特异性的协同性Ly-1⁺23⁻辅助性T细胞。
Eur J Immunol. 1980 Apr;10(4):231-6. doi: 10.1002/eji.1830100402.
5
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
6
Selective reconstitution of nude mice with long-term cultured and cloned specific helper T cells.用长期培养和克隆的特异性辅助性T细胞对裸鼠进行选择性重建。
Nature. 1980 Feb 21;283(5749):780-1. doi: 10.1038/283780a0.
7
Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
J Exp Med. 1980 Jan 1;151(1):194-203. doi: 10.1084/jem.151.1.194.
8
Clonal induction of helper T cells: conversion of specific signals into nonspecific signals.辅助性T细胞的克隆诱导：将特异性信号转化为非特异性信号。
Int Arch Allergy Appl Immunol. 1980;61(2):227-37. doi: 10.1159/000232437.
9
Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
10
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.

载体特异性T细胞的各个克隆以独特型和同种型异质性方式辅助抗半抗原B细胞应答。

Individual clones of carrier-specific T cells help idiotypically and isotypically heterogeneous anti-hapten B-cell responses.

作者信息

Cammisuli S, Schreier M H

出版信息

Immunology. 1981 Jul;43(3):581-9.

PMID:6166550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555052/
Abstract

We have established lines and clones of helper T cells specific for the antigen fowl gamma globulin (FGG) and maintained these cells in continuous proliferation in vitro for up to 8 months. During this period the specific helper activity was assessed in vitro in T cell-dependent anti-hapten responses. These pure populations of FGG-specific helper T cells provide help in the absence of other T cells for the induction of B cells to produce specific antibody of different isotypes and idiotypes. The same clones of specific helper T cells can provide help for a T cell-dependent antibody response against azobenzene arsonate (ARS), dinitrophenol (DNP) or phosphorylcholine (PC). With the exception of one clone all FGG-specific helper T cells (TFGG) promoted anti-hapten responses only when the hapten was covalently bound to the specific carrier. Help was only provided when T cells and T-depleted spleen cells were H-2 compatible to the left of the I-B region.

摘要

我们已经建立了对禽γ球蛋白（FGG）抗原具有特异性的辅助性T细胞系和克隆，并在体外使其持续增殖长达8个月。在此期间，在依赖T细胞的抗半抗原反应中对特异性辅助活性进行了体外评估。这些FGG特异性辅助性T细胞的纯群体在没有其他T细胞的情况下，为诱导B细胞产生不同同种型和独特型的特异性抗体提供帮助。相同的特异性辅助性T细胞克隆可以为针对偶氮苯砷酸盐（ARS）、二硝基苯酚（DNP）或磷酸胆碱（PC）的依赖T细胞的抗体反应提供帮助。除了一个克隆外，所有FGG特异性辅助性T细胞（TFGG）仅在半抗原与特异性载体共价结合时才促进抗半抗原反应。只有当T细胞和T细胞耗竭的脾细胞在I-B区域左侧的H-2相容时才提供帮助。