McNeilly A S, Tsonis C G, Baird D T
MRC Reproductive Biology Unit, University of Edinburgh, UK.
Hum Reprod. 1988 Jan;3(1):45-9. doi: 10.1093/oxfordjournals.humrep.a136650.
Inhibin is a glycoprotein which specifically inhibits FSH secretion. In follicular fluid, several forms of inhibin have been identified with mol. wts between 120 and 32 kd. The smallest active form is a glycosylated 32-kd protein with an 18-kd A chain and a 13-kd B chain. The secretion of inhibin by granulosa cells of the follicle is stimulated by FSH and testosterone, but not LH, and treatment of women with clomiphene and HMG/FSH results in an increase in the plasma concentration of inhibin. However, during the follicular phase of the normal menstrual cycle, FSH is inhibited mainly by oestradiol and inhibin levels remain constant or decline in parallel with those of FSH. It is probable that inhibin and oestradiol act together to cause the suppression of FSH. During the luteal phase, the human corpus luteum under the influence of LH secretes inhibin as well as oestradiol and progesterone. This combined negative feedback signal from the corpus luteum accounts for the suppression of FSH release and thus the failure of follicular growth during the luteal phase.
抑制素是一种糖蛋白，它能特异性抑制促卵泡激素（FSH）的分泌。在卵泡液中，已鉴定出几种分子量在120至32kd之间的抑制素形式。最小的活性形式是一种糖基化的32kd蛋白，由一条18kd的A链和一条13kd的B链组成。卵泡颗粒细胞分泌抑制素受FSH和睾酮刺激，但不受黄体生成素（LH）刺激，用克罗米芬和人绝经期促性腺激素/促卵泡激素（HMG/FSH）治疗女性会导致血浆抑制素浓度升高。然而，在正常月经周期的卵泡期，FSH主要受雌二醇抑制，抑制素水平保持恒定或与FSH水平平行下降。抑制素和雌二醇可能共同作用导致FSH的抑制。在黄体期，人黄体在LH的影响下分泌抑制素以及雌二醇和孕酮。来自黄体的这种联合负反馈信号导致FSH释放受到抑制，从而导致黄体期卵泡生长失败。
