University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Copenhagen, Denmark.
Biomed J. 2020 Apr;43(2):99-106. doi: 10.1016/j.bj.2020.04.001. Epub 2020 Apr 22.
Despite the hard times COVID-19 has imposed on us, the Biomedical Journal strives to provide fresh and compelling reading material - to be enjoyed safely from home. In this issue, we glance behind the scenes of dental stem cell preservation for potential therapeutic use, and discover that cancer cells hijack podoplanin expression to induce thrombosis. Moreover, we learn how the helicase DDX17 promotes tumour stemness, how genetic defects in meiosis and DNA repair cause premature ovarian insufficiency, and that the brain-derived neurotrophic factor is associated with several psychiatric diseases. Further accounts relate the role of miR-95-3p in colorectal cancer, the protective power of eggplants against mercury poisoning, and the predictive value of inhibin A for premature delivery. Finally, the very rare case of adenoid cystic carcinoma in the external auditory canal receives some attention, and we get to read up on how 3D imaging and modelling combines functional and aesthetic repair of cleft lip and palate cases.
尽管 COVID-19 给我们带来了困难时期，但《生物医学期刊》努力提供新鲜而引人入胜的阅读材料——在家中安全享受。在本期中，我们窥探了牙科干细胞保存的幕后，以寻找潜在的治疗用途，并发现癌细胞劫持 podoplanin 表达以诱导血栓形成。此外，我们了解了解旋酶 DDX17 如何促进肿瘤干细胞特性，减数分裂和 DNA 修复中的遗传缺陷如何导致卵巢早衰，以及脑源性神经营养因子与几种精神疾病有关。进一步的研究还涉及 miR-95-3p 在结直肠癌中的作用、茄子对汞中毒的保护作用以及抑制素 A 对早产的预测价值。最后，外耳道腺样囊性癌这一非常罕见的病例也受到了一些关注，我们了解到 3D 成像和建模如何结合功能和美学修复唇腭裂病例。
