Scott J, Flower E A, Burns J
Department of Dental Surgery, University of Liverpool, England.
J Oral Pathol. 1987 Nov;16(10):505-10. doi: 10.1111/j.1600-0714.1987.tb00681.x.
Parotid samples from 63 'sudden death' necropsies of both sexes, aged 17-90 years, were collected after exclusions for chronic illness or medications. Advancing age was accompanied by acinar atrophy and ductal irregularities. The adipose content varied widely at all ages but, together with fibrovascular tissue, tended to increase with age. Stereological analysis demonstrated a linear reduction of acinar proportional volume amounting to 30% over the age range. Females tended to have more adipose tissue and less fibrous tissue than males. These structural age changes resemble those of other salivary glands, but unlike the latter are not accompanied by age-dependent functional impairments. This suggests a greater acinar secretory efficiency or larger secretory reserve volume in the parotid than in other glands. The frequent high levels of parotid adiposity encountered suggest this feature is not pathological nor necessarily a reliable indicator of nutritional or hormonal diseases, excluded from the present study.
收集了63例年龄在17至90岁之间、因慢性疾病或药物治疗而被排除在外的男女“猝死”尸检的腮腺样本。随着年龄的增长，腺泡萎缩和导管不规则。脂肪含量在所有年龄段差异很大，但与纤维血管组织一起，往往随着年龄的增长而增加。体视学分析表明，在整个年龄范围内，腺泡比例体积呈线性下降，降幅达30%。女性往往比男性有更多的脂肪组织和更少的纤维组织。这些结构上的年龄变化与其他唾液腺相似，但与后者不同的是，它们没有伴随年龄依赖性的功能损害。这表明腮腺的腺泡分泌效率更高或分泌储备体积比其他腺体更大。所遇到的腮腺肥胖症频繁出现的高水平表明，这一特征既不是病理性的，也不一定是营养或激素疾病的可靠指标，本研究已将其排除。
