Scott J, Burns J, Flower E A
School of Dental Surgery, University of Liverpool.
J Clin Pathol. 1988 Aug;41(8):837-40. doi: 10.1136/jcp.41.8.837.
A quantitative histological analysis of the major salivary glands was carried out at necropsy in 28 alcoholics and in a series of age and sex matched controls. The findings were related to the different types of histologically diagnosed liver disease present. Significant quantitative changes of salivary gland structure were noted in cirrhosis but not in other forms of alcoholic liver disease. In cirrhotic subjects the parotid contained proportionally more adipose but less acinar tissues than in controls. The submandibular gland showed a proportional increase in adiposity and reduction in fibrovascular tissues but no noticeable reduction in its acinar proportional volume. Neither grossly detectable parotid enlargement nor acinar hypertrophy, a feature which has previously been noted as characteristic of alcoholic sialadenosis, were evident in this series. These findings provide little structural support for the reportedly increased secretory capacity of salivary glands in chronic alcohol abuse.
对28名酗酒者以及一系列年龄和性别匹配的对照者进行了尸检，对主要唾液腺进行了定量组织学分析。研究结果与存在的不同类型组织学诊断的肝脏疾病有关。在肝硬化患者中发现了唾液腺结构的显著定量变化，而在其他形式的酒精性肝病中未发现。与对照组相比，肝硬化患者的腮腺中脂肪组织比例更高，但腺泡组织更少。下颌下腺的脂肪含量成比例增加，纤维血管组织减少，但其腺泡比例体积没有明显减少。在该系列研究中，未发现明显可检测到的腮腺肿大或腺泡肥大，而腺泡肥大此前被认为是酒精性涎腺增生的特征。这些发现几乎没有为慢性酒精滥用时唾液腺分泌能力据称增加提供结构上的支持。
