评价亚洲裔人群的条带角膜厚度计、泪膜高度和深度在干眼病诊断中的应用。

Evaluation of strip meniscometry, tear meniscus height and depth in the diagnosis of dry eye disease in asian Indian eyes.

机构信息

Cornea & Ocular Surface Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.

出版信息

Ocul Surf. 2019 Oct;17(4):747-752. doi: 10.1016/j.jtos.2019.07.002. Epub 2019 Jul 3.

DOI:10.1016/j.jtos.2019.07.002

PMID:31276830

Abstract

PURPOSE

Evaluate role of Strip Meniscometry (SMT) and lower tear meniscus [height (LTMH) & depth (LTMD)] in diagnosis of Dry Eye Disease (DED) and its comparison with TBUT.

METHODS

In a prospective observational cross-sectional study of 120 eyes [60 eyes of 30 DED (Group 1) & 60 eyes of 30 controls (Group 2)] TBUT, Schirmer's, SMT, LTMH and LTMD was done. Subjects >18 years diagnosed with DED (aqueous deficient) as per Tear film and Ocular surface society-Dry Eye Workshop (TFOS DEWS) II protocol and Ocular surface disease Index (OSDI) questionnaire, with no associated systemic risk factor and previous ocular medical/surgical treatment were included as cases and subjects with no history of ocular surface disease as controls. The data was analyzed using t-test & receiver operating characteristic curve.

RESULTS

TBUT & Schirmer's values were significantly lower in group 1 (p < 0.05). SMT was 2.28 ± 1.28 (Range 0-6) & 8.11 ± 1.39 (Range 3-10) in group 1 & 2 respectively (p < 0.05). LTMH was 169.32 ± 29.84 μm (Range 85.78-209.11) and 234.41 ± 19.51 μm (Range 203.89-289.53) in Group 1 & 2 respectively (p < 0.05). LTMD was 144.32 ± 33.60 μm (Range 57.49-190.12) and 206.69 ± 14.17 μm (Range 187.12-251.50) in Group 1 & 2 respectively (p < 0.05). The SMT, LTMH and LTMD showed a cutoff value of < 5 mm (AUC 0.994, sensitivity 96.7%, specificity 96.7%), 204.96 μm (AUC 0.998, sensitivity 98.3%, specificity 96.7%) & 190 μm (AUC 0.995, sensitivity 96.7%, specificity 95%) respectively.

CONCLUSION

SMT, ASOCT, LTMD & LTMH are useful non invasive diagnostic tests for DED comparable with TBUT.

摘要

目的

评估Strip Meniscometry（SMT）和下泪膜半月板[高度（LTMH）和深度（LTMD）]在干眼病（DED）诊断中的作用，并与 TBUT 进行比较。

方法

在一项前瞻性观察性横断面研究中，对 120 只眼睛[30 只 DED （第 1 组）的 60 只眼睛和 30 只对照（第 2 组）的 60 只眼睛]进行了 TBUT、Schirmer's、SMT、LTMH 和 LTMD 检查。根据泪膜和眼表面协会-干眼病工作坊（TFOS DEWS）II 协议和眼表面疾病指数（OSDI）问卷，将年龄>18 岁、被诊断为 DED（水液缺乏型）且无相关系统性风险因素和既往眼部医疗/手术治疗的患者纳入病例组，并将无眼部表面疾病史的患者纳入对照组。使用 t 检验和受试者工作特征曲线对数据进行分析。

结果

第 1 组的 TBUT 和 Schirmer's 值明显较低（p<0.05）。第 1 组和第 2 组的 SMT 分别为 2.28±1.28（范围 0-6）和 8.11±1.39（范围 3-10）（p<0.05）。第 1 组和第 2 组的 LTMH 分别为 169.32±29.84μm（范围 85.78-209.11）和 234.41±19.51μm（范围 203.89-289.53）（p<0.05）。第 1 组和第 2 组的 LTMD 分别为 144.32±33.60μm（范围 57.49-190.12）和 206.69±14.17μm（范围 187.12-251.50）（p<0.05）。SMT、LTMH 和 LTMD 的截断值分别为<5mm（AUC 0.994，灵敏度 96.7%，特异性 96.7%）、204.96μm（AUC 0.998，灵敏度 98.3%，特异性 96.7%）和 190μm（AUC 0.995，灵敏度 96.7%，特异性 95%）。