Martínez-Plaza Elena, Barberán-Bernardos Laura, Molina-Martín Ainhoa, Piñero David P
Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain.
University of Valladolid, 47001 Valladolid, Spain.
Diagnostics (Basel). 2024 Oct 12;14(20):2276. doi: 10.3390/diagnostics14202276.
To evaluate the accuracy of diagnosing dry eye disease (DED) by using the Visionix VX120+, to establish reference values for tear meniscus height (TMH) and non-invasive break-up time (NIBUT), and to compare the NIBUT measurements with the fluorescein tear break-up time (FBUT), Methods: fifty-eight subjects (34 dry eye and 24 control) were enrolled. The TMH, first NIBUT, and NIBUT50% were evaluated with the Visionix VX120+, and the FBUT was measured with a slit-lamp. The Receiver Operating Characteristic (ROC) curve was used to evaluate the diagnostic performance, and the Bland-Altman method was performed to analyze the agreement.
The areas under the curve were 0.62, 0.60, and 0.70 for the TMH, first NIBUT, and NIBUT50%, respectively. The optimal cut-off values (sensitivity, specificity) were 0.29 (0.62, 0.67), 5.05 (0.85, 0.46), and 7.35 (0.65, 0.79) for the TMH, first NIBUT, and NIBUT50%, respectively. The mean differences (lower, upper limits of agreement) were -1.10 (-8.78, 6.58) and 1.55 (-5.68, 8.78) for the first NIBUT vs. FBUT and the NIBUT50% vs. FBUT, respectively.
In conclusion, the NIBUT50% can be a useful tool for dry eye screening, with acceptable values of sensitivity and specificity. First, the NIBUT and NIBUT50% should not be used interchangeably with the FBUT.
评估使用Visionix VX120+诊断干眼病（DED）的准确性，建立泪河高度（TMH）和非侵入性泪膜破裂时间（NIBUT）的参考值，并将NIBUT测量值与荧光素泪膜破裂时间（FBUT）进行比较。方法：招募了58名受试者（34名干眼患者和24名对照者）。使用Visionix VX120+评估TMH、首次NIBUT和NIBUT50%，并使用裂隙灯测量FBUT。采用受试者工作特征（ROC）曲线评估诊断性能，并采用Bland-Altman方法分析一致性。
TMH、首次NIBUT和NIBUT50%的曲线下面积分别为0.62、0.60和0.70。TMH、首次NIBUT和NIBUT50%的最佳截断值（敏感性、特异性）分别为0.29（0.62，0.67）、5.05（0.85，0.46）和7.35（0.65，0.79）。首次NIBUT与FBUT以及NIBUT50%与FBUT的平均差异（一致性下限、上限）分别为-1.10（-8.78，6.58）和1.55（-5.68，8.78）。
总之，NIBUT50%可作为干眼筛查的有用工具，其敏感性和特异性值可接受。首先，NIBUT和NIBUT50%不应与FBUT互换使用。
